Zhu Feng, Wang Zihan, Song Jianghua, Ji Yan
Department of Neurology, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, No. 60 Middle Qingnian Road, Nantong, 226001, Jiangsu, China.
Nantong University Medical School, No.19 Qixiu Road, Nantong, 226001, Jiangsu, China.
Sci Rep. 2024 Aug 1;14(1):17772. doi: 10.1038/s41598-024-66279-4.
Stroke is the second leading cause of death worldwide, and China has the highest stroke incidence in the world. The systemic inflammatory response index (SIRI), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), neutrophil-to-high-density lipoprotein ratio (NHR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) have clinical in predicting the prognosis of acute ischaemic stroke (AIS) patients. No studies have compared the predictive value of these six composite inflammatory markers. This study included 516 AIS patients with AIS symptoms for < 24 h. The short-term prognosis of AIS patients at 30 days was assessed using the modified Rankin scale (mRS), an mRS score > 2 defining poor prognosis. The results of the univariate analysis showed that all six composite inflammatory indices, SIRI, SII, NHR, NLR, PLR and MLR, were associated with a poor prognosis in patients with AIS. All six composite inflammatory indicators correlated with the short-term prognosis of AIS patients. The six composite inflammation indicators were included in the binary logistic regression, and the results showed that SIRI, NLR and PLR were found to be independent risk factors for poor short-term prognosis in AIS patients. Among the six inflammatory markers, SIRI, NLR and PLR were the most clinically valuable for predicting the short-term prognosis of patients with AIS. Peripheral blood indices are easy to obtain clinically and can provide important clinical value for early prognosis and treatment adjustment.
中风是全球第二大致死原因，中国是世界上中风发病率最高的国家。全身炎症反应指数（SIRI）、全身免疫炎症指数（SII）、中性粒细胞与高密度脂蛋白比值（NHR）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及单核细胞与淋巴细胞比值（MLR）在预测急性缺血性中风（AIS）患者的预后方面具有临床意义。尚无研究比较这六种复合炎症标志物的预测价值。本研究纳入了516例症状出现时间<24小时的AIS患者。采用改良Rankin量表（mRS）评估AIS患者30天时的短期预后，mRS评分>2定义为预后不良。单因素分析结果显示，所有六种复合炎症指标，即SIRI、SII、NHR、NLR、PLR和MLR，均与AIS患者的预后不良相关。所有六种复合炎症指标均与AIS患者的短期预后相关。将这六种复合炎症指标纳入二元逻辑回归分析，结果显示SIRI、NLR和PLR是AIS患者短期预后不良的独立危险因素。在这六种炎症标志物中，SIRI、NLR和PLR对预测AIS患者的短期预后最具临床价值。外周血指标在临床上易于获取，可为早期预后评估和治疗调整提供重要的临床价值。
