Barik Archana, Rashmi Apoorva, Singh Vinita, Kumar Upadhyay Amitabh
Obstetrics and Gynaecology, Manipal Tata Medical College, Jamshedpur, IND.
Obstetrics and Gynaecology, Tata Main Hospital, Jamshedpur, IND.
Cureus. 2024 Dec 28;16(12):e76542. doi: 10.7759/cureus.76542. eCollection 2024 Dec.
Introduction Evidence suggests inflammation plays a key role in the development of ovarian malignancy. This study investigated the relationship between the C-reactive protein (CRP) to serum albumin (Alb) ratio and clinicopathological parameters in ovarian cancer patients. The goal was to determine if this readily measurable inflammatory marker could provide insights into disease severity. Methods A prospective study of 94 patients with histopathologically confirmed ovarian cancer (diagnosed between November 2020 and December 2023) investigated the relationship between the pretreatment C-reactive protein to albumin ratio (CRP/Alb), and various clinicopathological characteristics, including age, distant metastasis, lymph node involvement, ascites, tumor grade, and surgical stage. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic accuracy of the CRP/Alb ratio and establish a cutoff value. Results Patients with metastasis, lymph node involvement, ascites, higher tumor grade, and advanced stages (III and IV) had significantly higher median CRP/Alb ratios compared to those without these features (1.43 vs. 0.78, 1.47 vs. 0.51, 1.16 vs. 0.46, 1.46 vs. 0.52, and stages I/II (0.49/0.95) vs. stages III/IV (1.47/1.58), respectively; all p < 0.001). ROC analysis determined an optimal cutoff value of 1.08. A preoperative CRP/Alb ratio above this cutoff indicated severe disease based on clinicopathological parameters. Conclusion In conclusion, elevated pretreatment CRP/Alb ratios correlated with more severe and advanced ovarian cancer.
引言 有证据表明炎症在卵巢恶性肿瘤的发展中起关键作用。本研究调查了卵巢癌患者中C反应蛋白（CRP）与血清白蛋白（Alb）比值与临床病理参数之间的关系。目的是确定这种易于测量的炎症标志物是否能为疾病严重程度提供见解。方法 对94例经组织病理学确诊的卵巢癌患者（2020年11月至2023年12月期间诊断）进行前瞻性研究，调查预处理时C反应蛋白与白蛋白比值（CRP/Alb）与各种临床病理特征之间的关系，包括年龄、远处转移、淋巴结受累、腹水、肿瘤分级和手术分期。采用受试者工作特征（ROC）曲线分析评估CRP/Alb比值的诊断准确性并确定临界值。结果 与没有这些特征的患者相比，发生转移、淋巴结受累、有腹水、肿瘤分级较高以及处于晚期（III期和IV期）的患者的中位CRP/Alb比值显著更高（分别为1.43对0.78、1.47对0.51、1.16对0.46、1.46对0.52，以及I/II期（0.49/0.95）对III/IV期（1.47/1.58）；所有p<0.001）。ROC分析确定最佳临界值为1.08。术前CRP/Alb比值高于此临界值表明根据临床病理参数疾病严重。结论 总之，预处理时CRP/Alb比值升高与更严重和晚期的卵巢癌相关。
