Yu Shi-Tong, Zhou Zhiwei, Cai Qian, Liang Faya, Han Ping, Chen Renhui, Huang Xiao-Ming
Department of Otolaryngology, Head and Neck Surgery; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Onco Targets Ther. 2017 Feb 15;10:879-884. doi: 10.2147/OTT.S128391. eCollection 2017.
The present study was designed to retrospectively evaluate the prognostic value of the C-reactive protein/albumin (CRP/ALB) ratio in laryngeal squamous cell carcinoma (LSCC).
One hundred and twenty-nine newly diagnosed LSCC patients admitted between May 2006 and October 2011 were retrospectively reviewed. Their serum CRP and ALB were quantified preoperatively. The relationship between the CRP/ALB ratio and the clinicopathologic features was analyzed. Receiver operating characteristic curve was used to calculate the prognostic value of the CRP/ALB ratio. Then, the Cox proportional hazards model was used in univariate and multivariate analyses to identify significant prognostic factors associated with disease-free survival and overall survival.
The cutoff value for CRP/ALB ratio was 0.047. An elevated CRP/ALB ratio was significantly associated with nodal metastasis, late disease stage, and recurrence. Also, high values of CRP/ALB ratio were significant predictors for poor overall survival and disease-free survival on multivariate analysis.
Pretreatment CRP/ALB ratio may be a significant prognostic marker in LSCC.
本研究旨在回顾性评估C反应蛋白/白蛋白（CRP/ALB）比值在喉鳞状细胞癌（LSCC）中的预后价值。
回顾性分析2006年5月至2011年10月期间收治的129例新诊断的LSCC患者。术前对其血清CRP和ALB进行定量检测。分析CRP/ALB比值与临床病理特征之间的关系。采用受试者工作特征曲线计算CRP/ALB比值的预后价值。然后，使用Cox比例风险模型进行单因素和多因素分析，以确定与无病生存期和总生存期相关的显著预后因素。
CRP/ALB比值的临界值为0.047。CRP/ALB比值升高与淋巴结转移、疾病晚期和复发显著相关。此外，在多因素分析中，CRP/ALB比值高是总生存期和无病生存期差的显著预测指标。
治疗前CRP/ALB比值可能是LSCC的一个重要预后标志物。
