在丙型肝炎病毒（HCV）合并感染的献血者样本中鉴定出近乎全长的人pegivirus 2型（HPgV-2）基因组。
Identification of near full-length human pegivirus type 2 (HPgV-2) genomes in blood donor samples co-infected with hepatitis C virus (HCV).
作者信息
Ragupathy Viswanath, Kelley Kylan, Hewlett Indira
机构信息
Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
出版信息
Microbiol Resour Announc. 2025 Mar 11;14(3):e0117924. doi: 10.1128/mra.01179-24. Epub 2025 Jan 29.
Abstract
Human pegivirus (HPgV) identified from an HCV-infected plasma sample through nanopore metagenomics. The analysis revealed a nearly complete HPgV-2 genome. Phylogenetic analysis confirmed its classification within the HPgV-2 genotype, providing insights into viral co-infection dynamics. The metagenomics approach advances the understanding of viral diversity and supports the development of accurate diagnostics.
摘要
通过纳米孔宏基因组学技术从一份丙型肝炎病毒（HCV）感染的血浆样本中鉴定出人类pegivirus（HPgV）。分析揭示了一个近乎完整的HPgV-2基因组。系统发育分析证实了其在HPgV-2基因型中的分类，为病毒共感染动力学提供了见解。宏基因组学方法增进了对病毒多样性的理解，并支持准确诊断方法的开发。
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