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本文引用的文献

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Exploring Microorganisms Associated to Acute Febrile Illness and Severe Neurological Disorders of Unknown Origin: A Nanopore Metagenomics Approach.探索与急性发热疾病和不明原因严重神经疾病相关的微生物:一种纳米孔宏基因组学方法。
Genes (Basel). 2024 Jul 15;15(7):922. doi: 10.3390/genes15070922.
2
The Second Human Pegivirus, a Non-Pathogenic RNA Virus with Low Prevalence and Minimal Genetic Diversity.第二种人类杯状病毒,一种低流行率和最小遗传多样性的非致病性 RNA 病毒。
Viruses. 2022 Aug 23;14(9):1844. doi: 10.3390/v14091844.
3
Human Pegivirus Type 1: A Common Human Virus That Is Beneficial in Immune-Mediated Disease?人类戊型肝炎病毒 1 型:一种有益免疫介导性疾病的常见人类病毒?
Front Immunol. 2022 May 30;13:887760. doi: 10.3389/fimmu.2022.887760. eCollection 2022.
4
Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication.人类偏肺病毒综述:流行情况、传播途径、发病机制及临床意义。
Virulence. 2022 Dec;13(1):324-341. doi: 10.1080/21505594.2022.2029328.
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Brief Protocol for EDGE Bioinformatics: Analyzing Microbial and Metagenomic NGS Data.EDGE生物信息学简要方案:分析微生物和宏基因组NGS数据
Bio Protoc. 2017 Dec 5;7(23):e2622. doi: 10.21769/BioProtoc.2622.
6
Human pegivirus type 1 infection in Asia-A review of the literature.亚洲地区人类偏肺病毒 1 型感染:文献综述
Rev Med Virol. 2022 Jan;32(1):e2257. doi: 10.1002/rmv.2257. Epub 2021 May 26.
7
MEGA11: Molecular Evolutionary Genetics Analysis Version 11.MEGA11:分子进化遗传学分析版本 11。
Mol Biol Evol. 2021 Jun 25;38(7):3022-3027. doi: 10.1093/molbev/msab120.
8
Evidence that the second human pegivirus (HPgV-2) is primarily a lymphotropic virus and can replicate independent of HCV replication.有证据表明,第二种人类疱疹病毒(HPgV-2)主要是一种嗜淋巴细胞病毒,并且可以在不依赖 HCV 复制的情况下进行复制。
Emerg Microbes Infect. 2020 Feb 26;9(1):485-495. doi: 10.1080/22221751.2020.1730247. eCollection 2020.
9
Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR.通过生物信息学筛选和聚合酶链反应评估一种新型人佩吉病毒的病毒血症频率
Emerg Infect Dis. 2016 Apr;22(4):671-8. doi: 10.3201/eid2204.151812.
10
Discovery of a Novel Human Pegivirus in Blood Associated with Hepatitis C Virus Co-Infection.在与丙型肝炎病毒合并感染相关的血液中发现一种新型人pegivirus。
PLoS Pathog. 2015 Dec 11;11(12):e1005325. doi: 10.1371/journal.ppat.1005325. eCollection 2015 Dec.

在丙型肝炎病毒(HCV)合并感染的献血者样本中鉴定出近乎全长的人pegivirus 2型(HPgV-2)基因组。

Identification of near full-length human pegivirus type 2 (HPgV-2) genomes in blood donor samples co-infected with hepatitis C virus (HCV).

作者信息

Ragupathy Viswanath, Kelley Kylan, Hewlett Indira

机构信息

Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

出版信息

Microbiol Resour Announc. 2025 Mar 11;14(3):e0117924. doi: 10.1128/mra.01179-24. Epub 2025 Jan 29.

DOI:10.1128/mra.01179-24
PMID:39878481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11895448/
Abstract

Human pegivirus (HPgV) identified from an HCV-infected plasma sample through nanopore metagenomics. The analysis revealed a nearly complete HPgV-2 genome. Phylogenetic analysis confirmed its classification within the HPgV-2 genotype, providing insights into viral co-infection dynamics. The metagenomics approach advances the understanding of viral diversity and supports the development of accurate diagnostics.

摘要

通过纳米孔宏基因组学技术从一份丙型肝炎病毒(HCV)感染的血浆样本中鉴定出人类pegivirus(HPgV)。分析揭示了一个近乎完整的HPgV-2基因组。系统发育分析证实了其在HPgV-2基因型中的分类,为病毒共感染动力学提供了见解。宏基因组学方法增进了对病毒多样性的理解,并支持准确诊断方法的开发。