Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Rev Med Virol. 2022 Jan;32(1):e2257. doi: 10.1002/rmv.2257. Epub 2021 May 26.
The human pegivirus type 1 (HPgV-1)-as known as hepatitis G virus and GB virus C-is a common single-stranded RNA flavivirus. Because few studies have demonstrated an association between HPgV-1 infection and disease, screening for HPgV-1 is not performed routinely. Nonetheless, a beneficial impact of HPgV-1 infection on HIV disease progression has been reported in multiple studies. Given the burden of HIV in Asia and the complex interactions between viral co-infections and the host, we provide a comprehensive overview of the existing data from Asia on HPgV-1 infection, including the prevalence and circulating genotypes in all Asian countries with data reported. This review highlights the research conducted thus far and emphasizes the need for additional studies on HPgV-1 across the Asian continent.
人类杯状病毒 1 型（HPgV-1）——也被称为庚型肝炎病毒和 GB 病毒 C——是一种常见的单链 RNA 黄病毒。由于很少有研究表明 HPgV-1 感染与疾病之间存在关联，因此通常不会对其进行筛查。尽管如此，多项研究报告称，HPgV-1 感染对 HIV 疾病进展有有益影响。鉴于亚洲地区 HIV 的负担以及病毒合并感染与宿主之间的复杂相互作用，我们提供了亚洲地区有关 HPgV-1 感染的现有数据的全面概述，包括所有有数据报告的亚洲国家的流行率和循环基因型。这篇综述强调了迄今为止开展的研究，并强调需要在整个亚洲大陆对 HPgV-1 进行更多研究。
