沙鼠肾上腺线粒体的NADP - 异柠檬酸脱氢酶：对类固醇羟化作用的支持
NADP-isocitric dehydrogenase of gerbil adrenal mitochondria: support of steroid hydroxylation.
作者信息
McCarthy J L, Gauthier J
出版信息
Experientia. 1985 Apr 15;41(4):484-5. doi: 10.1007/BF01966160.
PMID:3987871
Abstract
In gerbil adrenal cortex the activity of intramitochondrial NADP-linked isocitric dehydrogenase (IDH) is up to 10-fold greater than the NAD-linked IDH. The NADP-IDH, apparent Km 0.58 mM, Vmax 280 nmoles/min/mg mitochondrial protein, appears to be the major source of reducing equivalents to support adrenal mitochondrial steroid 11B- and 19-hydroxylation in this species.
摘要
在沙鼠肾上腺皮质中，线粒体内与NADP相关的异柠檬酸脱氢酶（IDH）的活性比与NAD相关的IDH高10倍。NADP-IDH的表观Km为0.58 mM，Vmax为280纳摩尔/分钟/毫克线粒体蛋白，它似乎是该物种肾上腺线粒体类固醇11β-和19-羟化反应中还原当量的主要来源。
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