匙羹藤提取物的抗炎及伤口愈合特性评估。
Evaluation of anti-inflammatory and wound healing properties of Tinospora cordifolia extract.
作者信息
Das Shohag Chandra, Biswas Subrato, Khan Olin, Akter Rupa, Azad Md Abul Kalam, Sarkar Sujan Kumar, Masum Md Abdul, Bedoura Sultana
机构信息
Department of Dyes and Chemical Engineering, Bangladesh University of Textiles, Dhaka, Bangladesh.
Department of Anatomy, Histology & Physiology, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh.
出版信息
PLoS One. 2025 Jan 29;20(1):e0317928. doi: 10.1371/journal.pone.0317928. eCollection 2025.
Tinospora cordifolia extract exhibits diverse benefits-anti-arthritis, anti-malarial, anti-allergic, anti-diabetic, antihepatotoxic, and antipyretic effects. Its specific anti-inflammatory and healing capacities remain unexplored, prompting a study utilizing a mouse skin wound model and direct T. cordifolia extraction. UV-Vis spectroscopy depicted an absorption range of 200-400 nm, while FTIR analysis identified alcohols, phenols, amines, amides, aldehydes, ketones, alkanes, and alkenes. GC-MS analysis revealed the presence of components: 5methyl-5-Hexen-2-Ol, n-hexadecenoic acid, cholesta-4,6-dien-3beta-ol, stigmasterol, β-sitosterol, stearate which are present in the extract. Histopathological examination confirmed accelerated wound healing, showcasing reduced inflammation, restored blood vessels, collagen fibers, and swift epidermal closure. T. cordifolia extract exhibits promise in enhancing wound healing through its antibacterial, anti-inflammatory properties.
匙羹藤提取物具有多种益处——抗关节炎、抗疟疾、抗过敏、抗糖尿病、抗肝毒性和解热作用。其特定的抗炎和愈合能力尚未得到探索，这促使人们利用小鼠皮肤伤口模型和直接的匙羹藤提取物进行一项研究。紫外可见光谱显示吸收范围为200 - 400纳米，而傅里叶变换红外光谱分析鉴定出了醇类、酚类、胺类、酰胺类、醛类、酮类、烷烃和烯烃。气相色谱 - 质谱联用分析揭示了提取物中存在以下成分：5 - 甲基 - 5 - 己烯 - 2 - 醇、正十六碳烯酸、胆甾 - 4,6 - 二烯 - 3β - 醇、豆甾醇、β - 谷甾醇、硬脂酸盐。组织病理学检查证实伤口愈合加速，表现为炎症减轻、血管恢复、胶原纤维生成以及表皮迅速闭合。匙羹藤提取物通过其抗菌、抗炎特性在促进伤口愈合方面展现出前景。
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