Carneiro Bruno Hassunuma, Breda Giovanni Luis, Cognialli Regielly Caroline Raimundo, Santos Germana Davila Dos, Vicente Vania Aparecida, Perondi Eduardo Gnoatto, França João Cesar Beenke, Queiroz-Telles Flávio
Universidade Federal do Paraná, Hospital de Clínicas, Curitiba, PR, Brasil.
Universidade Federal do Paraná, Departamento de Clínica Médica, Programa de pós-graduação em Medicina Interna e Ciências da Saúde, Curitiba, PR, Brasil.
Rev Soc Bras Med Trop. 2025 Jan 27;58. doi: 10.1590/0037-8682-0297-2024. eCollection 2025.
Cryptococcal disease is the third most common invasive fungal infection in solid organ transplant recipients and is associated with high-morbidity and -mortality rates. Donor-derived Cryptococcus spp. infection typically manifests within the first month post-procedure and has historically been caused by C. neoformans complex, predominantly in kidney recipients, but also after liver transplantation. We report the first documented case of donor-derived, early-onset C. gattii complex meningoencephalitis following liver transplantation in a 54-year-old woman, successfully treated with amphotericin B and fluconazole, and review the relevant literature.
隐球菌病是实体器官移植受者中第三常见的侵袭性真菌感染，与高发病率和死亡率相关。供体来源的隐球菌属感染通常在术后第一个月内出现，历史上一直由新生隐球菌复合体引起，主要发生在肾移植受者中，但肝移植后也有发生。我们报告了首例记录在案的肝移植后供体来源的早发性加蒂隐球菌复合体脑膜脑炎病例，该病例发生在一名54岁女性身上，经两性霉素B和氟康唑成功治疗，并对相关文献进行了综述。
