Wang Rui, Wang Han, Yao Rui, Li Yan, Manar Sedrati, Nie Lei, Yunusov Khaydar E, Pan Jianwei, Jiang Guohua
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou 310018, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou China.
Int J Pharm. 2025 Feb 25;671:125290. doi: 10.1016/j.ijpharm.2025.125290. Epub 2025 Jan 27.
An iontophoresis-driven porous microneedles (IPMNs) system has been developed for hyperuricemia management, which can be effectively prolong the anti-hyperuricemia effect. Porous microneedles (PMNs) with good biocompatibility, high porous volume, and excellent substance exchange capacity were firstly prepared for drug transdermal delivery and active iontophoresis.In vitro experiments showed that the transdermal delivery efficiency of anti-hyperuricemia drug (Allopurinol, AP) could be controlled using the iontophoresis current of IPMNs system. The AP release amount could be increased to 1.54 mg with iontophoresis under constant voltage of 1.5 V for 30 min. In vivo transdermal delivery of AP on mice models using IPMNs system exhibited an effective anti-hyperuricemia response. The serum uric acid (SUA) level could be dropped to ∼ 158.2 μmol/L within 2 h, and maintaining for 7 h under the normal level, leading a long-term therapeutic effect. This IPMNs system exhibits a low cost, user-friendly, and active delivery, showing great potential for hyperuricemia self-administration.
一种离子电渗驱动的多孔微针（IPMNs）系统已被开发用于高尿酸血症的治疗，它可以有效延长抗高尿酸血症的效果。首先制备了具有良好生物相容性、高孔隙率和优异物质交换能力的多孔微针（PMNs）用于药物透皮给药和主动离子电渗。体外实验表明，使用IPMNs系统的离子电流可以控制抗高尿酸血症药物（别嘌醇，AP）的透皮给药效率。在1.5V恒压下进行30分钟的离子电渗，AP释放量可增加到1.54mg。使用IPMNs系统在小鼠模型上进行AP的体内透皮给药表现出有效的抗高尿酸血症反应。血清尿酸（SUA）水平可在2小时内降至约158.2μmol/L，并在正常水平下维持7小时，产生长期治疗效果。这种IPMNs系统具有低成本、用户友好和主动给药的特点，在高尿酸血症自我给药方面显示出巨大潜力。
