Department of Science Education/Creative Convergent Manufacturing Engineering, Dankook University, Yongin, 16890, South Korea.
Nano-Convergence Mechanical Systems Research Division, Korea Institute of Machinery and Materials, Daejeon, 34103, South Korea.
Sci Rep. 2020 Feb 6;10(1):2027. doi: 10.1038/s41598-020-58822-w.
A multifunctional system comprised of hyaluronic acid microneedles was developed as an effective transdermal delivery platform for rapid local delivery. The microneedles can regulate the filling amount on the tip, by controlling the concentration of hyaluronic acid solution. Ultrasonication induces dissolution of the HA microneedles via vibration of acoustic pressure, and AC iontophoresis improves the electrostatic force-driven diffusion of HA ions and rhodamine B. The effect of ultrasound on rhodamine release was analyzed in vitro using a gelatin hydrogel. The frequency and voltage dependence of the AC on the ion induction transfer was also evaluated experimentally. The results showed that the permeability of the material acts as a key material property. The delivery system based on ultrasonication and iontophoresis in microneedles increases permeation, thus resulting in shorter initial delivery time than that required by delivery systems based on passive or ultrasonication alone. This study highlights the significance of the combination between ultrasonic waves and iontophoresis for improving the efficiency of the microneedles, by shortening the reaction duration. We anticipate that this system can be extended to macromolecular and dependence delivery, based on drug response time.
一种由透明质酸微针组成的多功能系统被开发为一种有效的透皮给药平台，用于快速局部给药。微针可以通过控制透明质酸溶液的浓度来调节尖端的填充量。超声空化通过声压的振动诱导 HA 微针的溶解，而 AC 离子电渗则改善了 HA 离子和罗丹明 B 的静电驱动力驱动的扩散。使用明胶水凝胶在体外分析了超声对罗丹明释放的影响。还通过实验评估了 AC 对离子感应传递的频率和电压依赖性。结果表明，材料的渗透性是一种关键的材料特性。基于微针中超声和离子电渗的输送系统增加了渗透性，从而导致初始输送时间比基于被动或单独超声的输送系统所需的时间更短。这项研究强调了超声波和离子电渗相结合对于提高微针效率的重要性，通过缩短反应时间。我们预计，根据药物反应时间，该系统可以扩展到用于大分子和依赖性药物的输送。
