Zhang Feng, Li Tao, Wan Junli, Wang Lu, Guo Wenmei, Hu Yue, Wang Hao, Bian Wei
Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Key Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, China.
Front Pharmacol. 2025 Jan 15;15:1521188. doi: 10.3389/fphar.2024.1521188. eCollection 2024.
Resveratrol, a polyphenolic compound commonly found in natural plants and fruits, exhibits potential in preventing optic nerve damage in glaucoma, as indicated by several animal studies. However, there is presently a dearth of relevant evidence available for comprehensive summarization.
In this study, we conducted an extensive search across 7 electronic databases, encompassing all pertinent animal studies for a systematic review and meta-analysis. Methodological quality was evaluated using SYRCLE's bias risk tool, with statistical analysis performed using Stata 17.0. The primary outcome measures included the survival of retinal ganglion cells and retinal thickness.
The comprehensive analysis of the 30 included studies revealed that resveratrol can enhance the expression of Sirtuin 1(SIRT1) protein in retinal tissue (SMD: 3.00, 95% CI: 2.46, 3.53, P = 0.095), boost the survival rate of retinal ganglion cells (SMD: 4.33, 95% CI: 3.28, 5.38, P < 0.05), decelerate the thinning of retinal thickness (SMD: 4.26, 95% CI: 2.77, 5.75, P < 0.05), and enhance visual function. Its potential mechanism of action may involve the suppression of pro-inflammatory cytokine levels and cell apoptosis.
Resveratrol emerges as a promising agent for mitigating glaucoma-related retinal damage. However, given that the animal research models utilized in the study may not fully reflect the intricate scenarios of multiple coexisting diseases in clinical settings, and the administration methods in animal models may differ from those in clinical practice, future studies should aim to provide higher levels of evidence to facilitate the clinical translation of these findings.
identifier [CRD42024535673].
白藜芦醇是一种常见于天然植物和水果中的多酚类化合物，多项动物研究表明，它在预防青光眼视神经损伤方面具有潜力。然而，目前缺乏可供全面总结的相关证据。
在本研究中，我们对7个电子数据库进行了广泛检索，纳入所有相关动物研究以进行系统评价和荟萃分析。使用SYRCLE的偏倚风险工具评估方法学质量，采用Stata 17.0进行统计分析。主要结局指标包括视网膜神经节细胞的存活情况和视网膜厚度。
对纳入的30项研究进行综合分析发现，白藜芦醇可提高视网膜组织中沉默调节蛋白1（SIRT1）的蛋白表达水平（标准化均数差：3.00，95%可信区间：2.46，3.53，P = 0.095），提高视网膜神经节细胞的存活率（标准化均数差：4.33，95%可信区间：3.28，5.38，P < 0.05），减缓视网膜厚度变薄（标准化均数差：4.26，95%可信区间：2.77，5.75，P < 0.05），并改善视觉功能。其潜在作用机制可能包括抑制促炎细胞因子水平和细胞凋亡。
白藜芦醇是减轻青光眼相关视网膜损伤的一种有前景的药物。然而，鉴于本研究中使用的动物研究模型可能无法完全反映临床环境中多种并存疾病的复杂情况，且动物模型中的给药方法可能与临床实践不同，未来的研究应致力于提供更高水平的证据，以促进这些研究结果的临床转化。
标识符[CRD42024535673]
