Al Oweidat Khaled, Toubasi Ahmad A, Khraisat Farah A, Al-Sayegh Thuraya N, Al-Harasis Layla M, Albtoosh Asma S
Department of Respiratory and Sleep Medicine, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
Faculty of Medicine, The University of Jordan, Amman, Jordan.
Int J Gen Med. 2025 Jan 25;18:391-402. doi: 10.2147/IJGM.S490196. eCollection 2025.
Bronchiectasis, a respiratory ailment, significantly impacts the life expectancy of individuals. This study aimed to explore the prevalence of multidrug-resistant organisms (MDROs) among bronchiectasis patients, the resistance patterns within various antibiotic classes, and the associated factors with these organisms.
A retrospective observational analysis was conducted on adult bronchiectasis patients attending clinics at Jordan University Hospital. The diagnosis of bronchiectasis was established through lung Computerized Tomography (CT) scans and clinical symptom assessment.
The study encompassed 235 patients, revealing a notably higher occurrence of MDROs among non-cystic fibrosis patients compared to their counterparts (P-value=0.001). Additionally, MDROs showed significant associations with the usage of inhaled beta agonists, anti-cholinergics, corticosteroids, and inhaled antibiotics (P-value<0.050). Patients with MDROs experienced a significantly elevated mean number of hospitalizations, exacerbations, and antibiotic courses compared to their counterparts (P-value<0.050). Moreover, those with MDROs exhibited a higher incidence of requiring O2 device support and faced an increased risk of mortality (P-value<0.050).
The observational nature of our study limits the associations in our study. However, we provided evidence that it is imperative for clinicians to assess their bronchiectasis patients for MDRO risk factors, facilitating appropriate initial antibiotic selection. Nevertheless, the validation of MDRO risk factors necessitates further exploration through larger studies with extended follow-up periods.
支气管扩张是一种呼吸系统疾病，严重影响患者的预期寿命。本研究旨在探讨支气管扩张患者中多重耐药菌（MDROs）的流行情况、各类抗生素的耐药模式以及与这些细菌相关的因素。
对约旦大学医院门诊的成年支气管扩张患者进行回顾性观察分析。通过肺部计算机断层扫描（CT）和临床症状评估确诊支气管扩张。
该研究纳入了235名患者，结果显示非囊性纤维化患者中MDROs的发生率明显高于囊性纤维化患者（P值=0.001）。此外，MDROs与吸入性β受体激动剂、抗胆碱能药物、皮质类固醇和吸入性抗生素的使用显著相关（P值<0.050）。与非MDROs患者相比，MDROs患者的平均住院次数、病情加重次数和抗生素疗程显著增加（P值<0.050）。此外，MDROs患者需要氧气设备支持的发生率更高，死亡风险也增加（P值<0.050）。
本研究的观察性质限制了研究中的关联。然而，我们提供的证据表明，临床医生必须评估支气管扩张患者的MDROs风险因素，以便进行适当的初始抗生素选择。尽管如此，MDROs风险因素的验证需要通过更大规模、更长随访期的研究进一步探索。
