潜伏性结核感染的诊断进展
Advances in the Diagnosis of Latent Tuberculosis Infection.
作者信息
Zhang Haiying, Guan Weiwei, Zhou Jikun
机构信息
School of Public Health at Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Tuberculosis, The Fifth Hospital of Shijiazhuang, Shijiazhuang, Hebei, People's Republic of China.
出版信息
Infect Drug Resist. 2025 Jan 25;18:483-493. doi: 10.2147/IDR.S504632. eCollection 2025.
Abstract
Latent tuberculosis infection (LTBI) is a critical stage of tuberculosis infection in which Mycobacterium tuberculosis (MTB) is dormant and does not cause active disease. Traditionally, the most commonly used clinical methods for diagnosing LTBI have been the tuberculin skin test (TST) and the interferon-gamma release assay (IGRA). Recently, however, novel skin tests, molecular biology techniques, and cytokine biomarkers have been developed. This review summarizes the latest research on the diagnosis of LTBI, highlighting new tools and methods to improve detection and differentiation from active tuberculosis(ATB).
摘要
潜伏性结核感染（LTBI）是结核感染的一个关键阶段，在此阶段结核分枝杆菌（MTB）处于休眠状态，不会引发活动性疾病。传统上，诊断LTBI最常用的临床方法是结核菌素皮肤试验（TST）和干扰素-γ释放试验（IGRA）。然而，近年来，新型皮肤试验、分子生物学技术和细胞因子生物标志物相继问世。本综述总结了LTBI诊断方面的最新研究，重点介绍了用于改善检测以及与活动性结核病（ATB）鉴别的新工具和方法。
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