Tsiara Eleni, Makri Sotiria, Skaperda Zoi, Giannakoulas Nikolaos, Vasilopoulos George, Kouretas Demetrios
Department of Hematology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, Mezourlo, Larissa 41110, Greece.
Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, Mezourlo, Larissa 41500, Greece.
Biomed Rep. 2025 Jan 14;22(3):45. doi: 10.3892/br.2025.1923. eCollection 2025 Mar.
Myelodysplastic syndrome (MDS) is a heterogeneous clonal disorder characterized by insufficient hematopoiesis, peripheral blood cytopenia and an increased risk for malignant transformation to acute myeloid leukemia. Several factors, such as age, sex and lifestyle, promote the development of MDS syndrome. Oxidative stress, along with its detrimental effects, cause hematological disorders; however, its role in the pathogenesis of MDS is unknown. The present study enrolled 50 patients with MDS and 50 additional healthy individuals to assess the endogenous antioxidant defense system by measuring specific redox biomarkers at the time of diagnosis. Glutathione (GSH) levels, catalase (CAT) activity and total antioxidant capacity (TAC) were measured in red blood cells, whereas levels of thiobarbituric acid reactive substances (TBARS) and protein carbonyls were measured in the plasma. A decrease in GSH levels, increased TBARS levels and TAC levels were observed in patients with MDS compared with healthy volunteers, supporting the hypothesis that oxidative stress disturbance could promote MDS.
骨髓增生异常综合征（MDS）是一种异质性克隆性疾病，其特征为造血不足、外周血细胞减少以及向急性髓系白血病恶性转化的风险增加。年龄、性别和生活方式等多种因素会促使MDS综合征的发展。氧化应激及其有害影响会导致血液系统疾病；然而，其在MDS发病机制中的作用尚不清楚。本研究纳入了50例MDS患者和另外50名健康个体，通过在诊断时测量特定的氧化还原生物标志物来评估内源性抗氧化防御系统。在红细胞中测量了谷胱甘肽（GSH）水平、过氧化氢酶（CAT）活性和总抗氧化能力（TAC），而在血浆中测量了硫代巴比妥酸反应性物质（TBARS）和蛋白质羰基水平。与健康志愿者相比，MDS患者的GSH水平降低、TBARS水平和TAC水平升高，这支持了氧化应激紊乱可促进MDS的假说。
