Patouna Anastasia, Sevdalis Panagiotis, Papanikolaou Konstantinos, Kourti Maria, Skaperda Zoi, Jamurtas Athanasios Z, Kouretas Demetrios
Department of Biochemistry-Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece.
Department of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece.
Biomed Rep. 2023 Mar 21;18(5):32. doi: 10.3892/br.2023.1614. eCollection 2023 May.
Honey is a natural product derived from the insect . Approximately 200 different compounds are included, making it a complex mixture with antimicrobial, antioxidant, and antidiabetic activity. Flavonoids and phenolic acids contained in honey are associated with its antioxidant capacity via mechanisms such as hydrogen donation and metallic ion chelation, although the exact antioxidant mechanism remains unknown. The aim of the present study was to: i) Estimate the antioxidant activity of a natural honey-based gel, commercially available under the trade name of 'Bear Strength honey gel' and to ii) assess the physiological and redox adjustments obtained after its consumption in healthy adult participants. For this purpose, 20 healthy participants (10 men and 10 women) included in their habitual diet 70 g of the honey-based gel for 14 days in a row. Pre- and post-consumption, physiological [weight, height, body mass index, body fat, waist-to-hip ratio, resting heart rate and blood pressure (BP)] and hematological (complete blood count) data were evaluated, along with the levels of five redox biomarkers: Glutathione (GSH), catalase (CAT), total antioxidant capacity (TAC), protein carbonyls (PCARBS) and thiobarbituric reactive substances (TBARS). The results revealed that the honey-based gel decreased the diastolic and mean arterial BP, especially in women, without affecting the rest of the physiological and hematological variables. Regarding the changes observed in antioxidant status variables, GSH was increased both in the total and women's group, while TAC was increased in all groups post-consumption. No changes were detected in the levels of CAT. Regarding oxidative stress, a decrease in the levels of TBARS in the total and women's group, was observed. PCARBS levels were decreased post-consumption only in the women's group. In conclusion, the present study demonstrated the potential positive effects of a honey-based gel on BP and redox status of healthy adults in a sex-specific manner.
蜂蜜是一种源自昆虫的天然产物。它包含约200种不同的化合物，是一种具有抗菌、抗氧化和抗糖尿病活性的复杂混合物。蜂蜜中含有的黄酮类化合物和酚酸通过氢供体和金属离子螯合等机制与其抗氧化能力相关，尽管确切的抗氧化机制尚不清楚。本研究的目的是：i）评估一种商品名为“熊力蜂蜜凝胶”的天然蜂蜜基凝胶的抗氧化活性，以及ii）评估健康成年参与者食用该凝胶后获得的生理和氧化还原调节情况。为此，20名健康参与者（10名男性和10名女性）连续14天在其日常饮食中摄入70克蜂蜜基凝胶。在食用前后，评估了生理数据[体重、身高、体重指数、体脂、腰臀比、静息心率和血压（BP）]和血液学数据（全血细胞计数），以及五种氧化还原生物标志物的水平：谷胱甘肽（GSH）、过氧化氢酶（CAT）、总抗氧化能力（TAC）、蛋白质羰基（PCARBS）和硫代巴比妥酸反应性物质（TBARS）。结果显示，蜂蜜基凝胶降低了舒张压和平均动脉压，尤其是在女性中，而不影响其他生理和血液学变量。关于抗氧化状态变量的变化，GSH在总体组和女性组中均增加，而TAC在食用后所有组中均增加。CAT水平未检测到变化。关于氧化应激，总体组和女性组中TBARS水平均下降。PCARBS水平仅在女性组食用后下降。总之，本研究以性别特异性方式证明了蜂蜜基凝胶对健康成年人血压和氧化还原状态的潜在积极影响。
