Hong Zhenmei, Zhang Shuijing, Zhang Shuqing, Zhao Yuqi, Ye Xiancong, Shu Xinxin, Chen Yufan, Yan Shuding, Ma Ruijie
Department of Neurology, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, China.
Department of Rehabilitation, Zhejiang Rehabilitation Medical Center, Hangzhou, China.
Front Neurol. 2025 Jan 15;15:1444873. doi: 10.3389/fneur.2024.1444873. eCollection 2024.
Alzheimer's disease (AD) is characterized by cognitive impairment and behavioral impairment. The gait of AD patients is attracting the increasing attention. The aim of this randomized controlled trial (RCT) is to explore the effect of acupuncture on the cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices.
In this RCT, a total of 108 AD patients will be randomly assigned into acupuncture group or control group for 8 weeks. The primary outcome will be three-dimensional gait analysis and cerebral hemodynamics using functional near-infrared spectroscopy (fNIRS). Secondary outcomes will include Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Barthel Index (BI).
This trial is expected to explore the effect of acupuncture on cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices for AD patients.
阿尔茨海默病（AD）的特征是认知障碍和行为障碍。AD患者的步态越来越受到关注。这项随机对照试验（RCT）的目的是探讨针刺对AD患者认知功能、步态表现和前额叶皮质血流动力学变化的影响。
在这项RCT中，总共108名AD患者将被随机分为针刺组或对照组，为期8周。主要结局将是使用功能近红外光谱（fNIRS）进行三维步态分析和脑血流动力学。次要结局将包括简易精神状态检查表（MMSE）、蒙特利尔认知评估量表（MoCA）和巴氏指数（BI）。
本试验有望探讨针刺对AD患者认知功能、步态表现和前额叶皮质血流动力学变化的影响。
