Mehta Aditya, Thomas Felix, Manubolu Venkat, Kinninger April, Budoff Matthew, Roy Sion K
Department of Medicine.
Department of Cardiology, Harbor-UCLA Medical Center.
Coron Artery Dis. 2025 Aug 1;36(5):416-421. doi: 10.1097/MCA.0000000000001495. Epub 2025 Jan 31.
Coronary artery calcium (CAC) scoring may be a useful tool for assessing cardiovascular disease in young adults, particularly in those with risk factors such as hypertension, dyslipidemia, or smoking. In this study, we aimed to address the risk factors for developing noncalcified plaque in young adults by assessing total plaque burden.
A single-center retrospective cohort study was conducted among 1026 consecutive patients aged 18-45 years who underwent CAC scoring and coronary computed tomography (CT) angiograms for clinical indications. CAC scores and total plaque scores (TPS) were calculated using standard scoring protocols. Multiple logistic regression analysis was conducted to identify independent risk factors of significant, noncalcified plaque in subjects where CAC = 0.
This single-center retrospective cohort study included 1026 patients aged 18-45 years who underwent CAC scoring and coronary CT angiograms for clinical indications. The mean age of the population was 38.8 years old. Sixty-three patients had a CAC score of 0 and a TPS >0. Of the patients with noncalcified plaque burden, 15% had a stenosis >50%, and 10% had a stenosis >70%. The odds of a subject having noncalcified plaque presence and CAC absent were significantly associated with being Hispanic, having diabetes, and having hyperlipidemia.
In young adults aged 18-45 years old, we found diabetes, hyperlipidemia, and being of Hispanic origin to be significantly associated with noncalcified plaque burden.
冠状动脉钙化（CAC）评分可能是评估年轻成年人心血管疾病的有用工具，尤其是对于那些有高血压、血脂异常或吸烟等危险因素的人。在本研究中，我们旨在通过评估总斑块负荷来探讨年轻成年人发生非钙化斑块的危险因素。
对1026例年龄在18 - 45岁之间因临床指征接受CAC评分和冠状动脉计算机断层扫描（CT）血管造影的连续患者进行单中心回顾性队列研究。使用标准评分方案计算CAC评分和总斑块评分（TPS）。对CAC = 0的受试者进行多因素逻辑回归分析，以确定显著非钙化斑块的独立危险因素。
这项单中心回顾性队列研究纳入了1026例年龄在18 - 45岁之间因临床指征接受CAC评分和冠状动脉CT血管造影的患者。人群的平均年龄为38.8岁。63例患者的CAC评分为0且TPS>0。在有非钙化斑块负荷的患者中，15%的患者狭窄>50%，10%的患者狭窄>70%。受试者存在非钙化斑块且无CAC与西班牙裔、患有糖尿病和患有高脂血症显著相关。
在18 - 45岁的年轻成年人中，我们发现糖尿病、高脂血症和西班牙裔与非钙化斑块负荷显著相关。
