Wu Ya-Xuan, Chen Yi-Chu, Jhuang Jing-Rong, Chiang Chun-Ju, Lee Wen-Chung
College of Public Health, Institute of Health Data Analytics and Statistics, National Taiwan University, Taipei, Taiwan.
College of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Ann Med. 2025 Dec;57(1):2458765. doi: 10.1080/07853890.2025.2458765. Epub 2025 Jan 30.
Despite global declines in cervical cancer incidence, certain regions observe unexpected rising trends among younger generations.
This study uses the age-period-cohort model to examine long-term incidence trends of invasive cervical cancer in Taiwan. Data were sourced from the Taiwan Cancer Registry.
From 2000 to 2019, both urban and rural areas of Taiwan saw a marked decrease in incidence rates, a trend largely attributed to the cytology-based screening program introduced in 1995. Yet, rising incidence rates emerged in younger Taiwanese generations, specifically those born post-1975 in urban and post-1980 in rural settings. The 1990-born urban cohort faced a risk 1.9 times higher than their 1975-born counterparts, while the risk for the 1990-born rural cohort was 1.4 times greater than those born in 1980. In addition, post-1980 urban cohorts exhibited greater risks than their rural counterparts.
The rising trends in cervical cancer incidence among younger Taiwanese generations may be influenced by factors such as increased sexual permissiveness and urbanization. Although current prevention efforts, such as human papillomavirus vaccination, are noteworthy, there is a need for ongoing surveillance and improved strategies that specifically target recent cohorts.
尽管全球宫颈癌发病率呈下降趋势，但某些地区在年轻一代中出现了意外的上升趋势。
本研究使用年龄-时期-队列模型来研究台湾地区浸润性宫颈癌的长期发病趋势。数据来源于台湾癌症登记处。
2000年至2019年期间，台湾城乡地区的发病率均显著下降，这一趋势在很大程度上归因于1995年引入的基于细胞学的筛查计划。然而，台湾年轻一代的发病率却出现了上升，特别是城市地区1975年后出生的人群以及农村地区1980年后出生的人群。1990年出生的城市队列面临的风险是1975年出生队列的1.9倍，而1990年出生的农村队列面临的风险是1980年出生队列的1.4倍。此外，1980年后出生的城市队列比农村队列面临更大的风险。
台湾年轻一代宫颈癌发病率的上升趋势可能受到性观念开放和城市化等因素的影响。尽管目前的预防措施，如人乳头瘤病毒疫苗接种，值得关注，但仍需要持续监测并改进针对近期队列的策略。
