Woodhouse K W, Bateman D N
Hum Toxicol. 1985 Jan;4(1):67-70. doi: 10.1177/096032718500400108.
Dothiepin induced symptoms of delayed gastric emptying in an elderly lady. Rechallenge studies were undertaken and demonstrated a delay in gastric emptying of liquid after re-administration of dothiepin at a time when plasma concentrations were 93 micrograms/l. Elderly patients may be more susceptible to the anticholinergic effects of tricyclic antidepressants on the gut.
多虑平在一位老年女性中诱发了胃排空延迟的症状。进行了再激发研究，结果表明在血浆浓度为93微克/升时再次给予多虑平后，液体胃排空出现延迟。老年患者可能对三环类抗抑郁药对肠道的抗胆碱能作用更敏感。
