Myers E D, Calvert E J
J Int Med Res. 1976;4(4):237-40. doi: 10.1177/030006057600400405.
Dothiepin was prescribed for 100 depressed out-patients alternately allocated to one of two groups. Patients in Group A were forewarned about side-effects and patients in Group B were not forewarned. None of the patients had previously received dothiepin. After two weeks the patients were questioned regarding side-effects and continuance with medication. Eighty-nine patients were included in the final analysis. The results failed to confirm the hypotheses that forewarning patients of side-effects causes a greater number of patients to complain of such effects, or that where patients experience side-effects, forewarning is associated with any less frequent discontinuance of therapy. Compared with a previous study with amitriptyline, the results of this study are much closer to statistical significance. This may be due to the lower overall incidence of side-effects with dothiepin and calls for further work with a larger sample of patients.
多虑平被开给100名抑郁症门诊患者，这些患者被交替分配到两个组中的一组。A组患者被告知副作用，B组患者未被告知。所有患者此前均未服用过多虑平。两周后，对患者进行关于副作用及是否继续用药的询问。最终分析纳入了89名患者。结果未能证实以下假设：提前告知患者副作用会导致更多患者抱怨这些副作用，或者在患者出现副作用的情况下，提前告知与治疗中断频率降低有关。与之前一项关于阿米替林的研究相比，本研究结果更接近统计学显著性。这可能是因为多虑平副作用的总体发生率较低，需要对更多患者样本进行进一步研究。
