Bergau Leonard, Sciacca Vanessa, Sohns Christian
Abteilung für Kardiologie/Pneumologie, Universitätsmedizin Göttingen, Göttingen, Deutschland.
Klinik für Elektrophysiologie/Rhythmologie, Ruhr-Universität Bochum, Bochum, Deutschland.
Herzschrittmacherther Elektrophysiol. 2025 Mar;36(1):3-9. doi: 10.1007/s00399-025-01066-w. Epub 2025 Jan 30.
Atrial fibrillation (AF) ablation is associated with a lower likelihood of death and surgical heart failure (HF) interventions in patients with HF. This effect is mainly driven by reduced all cause and cardiovascular death following ablation. Ablation also results in improved left ventricular (LV) function, decreased AF burden and AF regression. The accumulated evidence contributed substantially to a class 1 indication for AF ablation in patients with AF and HF with reduced ejection fraction in the 2023 ACC/AHA/ACCP/HRS guidelines. Risk scores like the CASTLE-HTx risk score may help to identify patients with HF who will particularly benefit from catheter ablation. The absolute benefit of catheter ablation is more pronounced in high-risk patients and is sustained over time. Catheter ablation should be considered as first-line therapy with a definitive class 1 indication for many patients with HF, particularly those with advanced HF.
心房颤动(AF)消融与心力衰竭(HF)患者死亡和手术性心力衰竭干预的可能性降低相关。这种效应主要由消融后全因死亡和心血管死亡减少所驱动。消融还可改善左心室(LV)功能、减轻房颤负担并使房颤逆转。累积证据在很大程度上促成了2023年美国心脏病学会(ACC)/美国心脏协会(AHA)/美国胸科医师学会(ACCP)/心律学会(HRS)指南中将AF消融列为射血分数降低的AF和HF患者的I类适应证。像CASTLE-HTx风险评分这样的风险评分可能有助于识别HF患者中特别能从导管消融中获益的患者。导管消融的绝对益处在高危患者中更为显著且随时间持续存在。对于许多HF患者,尤其是晚期HF患者,导管消融应被视为具有明确I类适应证的一线治疗。