Yuan Ziyue, Ye Jing, Liu Bo, Zhang Lan
Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Adv Biotechnol (Singap). 2024 Mar 21;2(2):14. doi: 10.1007/s44307-024-00021-z.
Autophagy serves as the primary intracellular degradation mechanism in which damaged organelles and self-cytoplasmic proteins are transported to the lysosome for degradation. Crohn's disease, an idiopathic chronic inflammatory disorder of the gastrointestinal tract, manifests in diverse regions of the digestive system. Recent research suggests that autophagy modulation may be a new avenue for treating Crohn's disease, and several promising small-molecule modulators of autophagy have been reported as therapeutic options. In this review, we discuss in detail how mutations in autophagy-related genes function in Crohn's disease and summarize the modulatory effects on autophagy of small-molecule drugs currently used for Crohn's disease treatment. Furthermore, we delve into the therapeutic potential of small-molecule autophagy inducers on Crohn's disease, emphasizing the prospects for development in this field. We aim to highlight the significance of autophagy modulation in Crohn's disease, with the aspiration of contributing to the development of more efficacious treatments that can alleviate their suffering, and improve their quality of life.
自噬是主要的细胞内降解机制，受损细胞器和自身细胞质蛋白通过该机制被转运至溶酶体进行降解。克罗恩病是一种胃肠道特发性慢性炎症性疾病，可出现在消化系统的不同部位。最近的研究表明，自噬调节可能是治疗克罗恩病的新途径，并且已有几种有前景的自噬小分子调节剂被报道可作为治疗选择。在本综述中，我们详细讨论了自噬相关基因突变在克罗恩病中的作用机制，并总结了目前用于治疗克罗恩病的小分子药物对自噬的调节作用。此外，我们深入探讨了小分子自噬诱导剂对克罗恩病的治疗潜力，强调了该领域的发展前景。我们旨在突出自噬调节在克罗恩病中的重要性，期望为开发更有效的治疗方法做出贡献，以减轻患者痛苦，提高其生活质量。
