• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

老年患者慢性瘙痒的局部用药:应对迫切需求

Topical Medications for Chronic Itch in Older Patients: Navigating a Pressing Need.

作者信息

Bartley Brooke, Pierce Christina, Hivnor Chad, Valdes-Rodriguez Rodrigo

机构信息

Department of Internal Medicine, Texas Health Presbyterian Dallas, Dallas, TX, USA.

University of Texas Health Science Center at San Antonio Long School of Medicine, San Antonio, TX, USA.

出版信息

Drugs Aging. 2025 Mar;42(3):213-233. doi: 10.1007/s40266-024-01174-1. Epub 2025 Jan 30.

DOI:10.1007/s40266-024-01174-1
PMID:39883297
Abstract

Chronic itch in older patients is a common problem, with a significant impact on quality of life. Chronic itch in the older population may be attributable to several causes, such as age-related changes, skin conditions, systemic conditions, medications, and psychological conditions. Given the complexity of itch in this population, comorbidities, and polypharmacy in most geriatric patients, treating chronic itch can be challenging for healthcare providers. Therefore, optimized topical treatment regimens are paramount to help these patients and prevent side effects.

摘要

老年患者的慢性瘙痒是一个常见问题,对生活质量有重大影响。老年人群中的慢性瘙痒可能归因于多种原因,如年龄相关变化、皮肤状况、全身状况、药物以及心理状况。鉴于该人群瘙痒问题的复杂性、大多数老年患者存在的合并症和多种药物治疗情况,治疗慢性瘙痒对医疗服务提供者而言可能具有挑战性。因此,优化的局部治疗方案对于帮助这些患者并预防副作用至关重要。

相似文献

1
Topical Medications for Chronic Itch in Older Patients: Navigating a Pressing Need.老年患者慢性瘙痒的局部用药:应对迫切需求
Drugs Aging. 2025 Mar;42(3):213-233. doi: 10.1007/s40266-024-01174-1. Epub 2025 Jan 30.
2
Chronic pruritus in the elderly: pathophysiology, diagnosis and management.老年人慢性瘙痒:病理生理学、诊断与管理
Drugs Aging. 2015 Mar;32(3):201-15. doi: 10.1007/s40266-015-0246-0.
3
Causes, pathophysiology, and treatment of pruritus in the mature patient.成年患者瘙痒的病因、病理生理学及治疗
Clin Dermatol. 2018 Mar-Apr;36(2):140-151. doi: 10.1016/j.clindermatol.2017.10.005. Epub 2017 Oct 17.
4
Itch Management in the Elderly.老年人的瘙痒管理
Curr Probl Dermatol. 2016;50:192-201. doi: 10.1159/000446094. Epub 2016 Aug 23.
5
From Compression to Itch: Exploring the Link Between Nerve Compression and Neuropathic Pruritus.从压迫到瘙痒:探索神经压迫与神经性瘙痒之间的联系。
Am J Clin Dermatol. 2025 Jan;26(1):23-33. doi: 10.1007/s40257-024-00898-5. Epub 2024 Oct 17.
6
Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus.P 物质和神经激肽 1 受体是治疗慢性瘙痒的新靶点。
Br J Dermatol. 2019 Nov;181(5):932-938. doi: 10.1111/bjd.18025. Epub 2019 Jun 6.
7
Effectiveness of topical clove oil on symptomatic treatment of chronic pruritus.局部用丁香油对慢性瘙痒症对症治疗的有效性。
J Cosmet Dermatol. 2017 Dec;16(4):508-511. doi: 10.1111/jocd.12342. Epub 2017 Apr 5.
8
Efficacy and safety of nemolizumab and topical corticosteroids for prurigo nodularis: results from a randomized double-blind placebo-controlled phase II/III clinical study in patients aged ≥ 13 years.尼莫利珠单抗联合外用皮质类固醇治疗结节性痒疹的疗效和安全性:一项在年龄≥13 岁患者中进行的随机、双盲、安慰剂对照的 II/III 期临床研究结果。
Br J Dermatol. 2024 Jul 16;191(2):200-208. doi: 10.1093/bjd/ljae131.
9
Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions.皮肤屏障损伤与瘙痒:机制、局部治疗及未来方向综述。
Acta Derm Venereol. 2019 Dec 1;99(13):1201-1209. doi: 10.2340/00015555-3296.
10
Management of Itch in the Elderly: A Review.老年人瘙痒的管理:综述
Dermatol Ther (Heidelb). 2019 Dec;9(4):639-653. doi: 10.1007/s13555-019-00326-1. Epub 2019 Sep 23.

本文引用的文献

1
Roflumilast Cream, 0.15%, for Atopic Dermatitis in Adults and Children: INTEGUMENT-1 and INTEGUMENT-2 Randomized Clinical Trials.0.15%罗氟司特乳膏用于成人和儿童特应性皮炎:INTEGUMENT-1和INTEGUMENT-2随机临床试验
JAMA Dermatol. 2024 Nov 1;160(11):1161-1170. doi: 10.1001/jamadermatol.2024.3121.
2
The Skin Acid Mantle: An Update on Skin pH.皮肤酸性保护膜:皮肤pH值的最新进展
J Invest Dermatol. 2025 Mar;145(3):509-521. doi: 10.1016/j.jid.2024.07.009. Epub 2024 Sep 5.
3
The treatment of Tofacitinib for rosacea through the inhibition of the JAK/STAT signaling pathway.
通过抑制 JAK/STAT 信号通路治疗酒渣鼻的托法替尼。
Arch Dermatol Res. 2024 Aug 24;316(8):566. doi: 10.1007/s00403-024-03314-4.
4
Topical corticosteroids in the era of new topical therapies: Balancing efficacy and safety for long-term use.新型局部治疗时代的外用糖皮质激素:平衡长期使用的疗效与安全性
J Eur Acad Dermatol Venereol. 2024 Jul;38(7):1236-1237. doi: 10.1111/jdv.20041.
5
Chronic Pruritus: A Review.慢性瘙痒症:综述。
JAMA. 2024 Jun 25;331(24):2114-2124. doi: 10.1001/jama.2024.4899.
6
Novel Topical Treatments for Itch.瘙痒的新型局部治疗方法
Dermatol Ther (Heidelb). 2024 Apr;14(4):829-840. doi: 10.1007/s13555-024-01144-w. Epub 2024 Apr 13.
7
Topical Calcineurin Inhibitors in the Management of Chronic Pruritus in Older Adults: A Research Letter.老年慢性瘙痒症管理中的局部钙调神经磷酸酶抑制剂:研究快报。
J Drugs Dermatol. 2024 Feb 1;23(2):e70-e72. doi: 10.36849/JDD.7190.
8
Roflumilast foam 0.3% for adolescent and adult patients with seborrheic dermatitis: A randomized, double-blinded, vehicle-controlled, phase 3 trial.罗氟司特泡沫 0.3%治疗青少年和成年脂溢性皮炎患者的随机、双盲、赋形剂对照、3 期临床试验。
J Am Acad Dermatol. 2024 May;90(5):986-993. doi: 10.1016/j.jaad.2023.12.065. Epub 2024 Jan 20.
9
Real-World Use of Ruxolitinib Cream: Safety Analysis at 1 Year.鲁索利替尼乳膏的真实世界应用:1 年安全性分析。
Am J Clin Dermatol. 2024 Mar;25(2):327-332. doi: 10.1007/s40257-023-00840-1. Epub 2024 Jan 19.
10
Rapid Improvements in Itch with Tapinarof Cream 1% Once Daily in Two Phase 3 Trials in Adults with Mild to Severe Plaque Psoriasis.在两项针对轻至重度斑块状银屑病成人患者的3期试验中,每日一次使用1%他扎罗芬乳膏可迅速改善瘙痒症状。
Dermatol Ther (Heidelb). 2024 Jan;14(1):201-211. doi: 10.1007/s13555-023-01068-x. Epub 2023 Dec 21.