Sun Han, Gong Qian, Fan Yuwei, Wang Yuxin, Wang Jia, Zhu Changliang, Mou Haijin, Yang Shufang, Liu Jin
Key Laboratory of Poyang Lake Environment and Resource Utilization, Ministry of Education, and Center for Algae Innovation & Engineering Research, School of Resources and Environment, Nanchang University, Nanchang, 330031, China.
Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, China.
Adv Biotechnol (Singap). 2024 Oct 8;2(4):36. doi: 10.1007/s44307-024-00044-6.
Microalgae offer a promising alternative for sustainable nutritional supplements and functional food ingredients and hold potential to meet the growing demand for nutritious and eco-friendly food alternatives. With the escalating impacts of global climate change and increasing human activities, microalgal production must be enhanced by reducing freshwater and land use and minimizing carbon emissions. The advent of 3D printing offers novel opportunities for optimizing microalgae production, though it faces challenges such as high production costs and scalability concerns. This work aims to provide a comprehensive overview of recent advancements in 3D-printed bioreactors for microalgal production, focusing on 3D printing techniques, bio-ink types, and their applications across environmental, food, and medical fields. This review highlights the benefits of 3D-printed bioreactors, including improved mass transfer, optimized light exposure, enhanced biomass yield, and augmented photosynthesis. Current challenges and future directions of 3D printing in microalgal production are also discussed to offer new insights into boosting microalgal cultivation efficiency for expanded applications.
微藻为可持续营养补充剂和功能性食品成分提供了一个有前景的替代方案，并且有潜力满足对营养丰富且环保的食品替代品日益增长的需求。随着全球气候变化影响的不断升级以及人类活动的增加，必须通过减少淡水和土地使用以及最大限度地减少碳排放来提高微藻产量。3D打印技术的出现为优化微藻生产提供了新的机遇，尽管它面临着生产成本高和可扩展性等挑战。这项工作旨在全面概述用于微藻生产的3D打印生物反应器的最新进展，重点关注3D打印技术、生物墨水类型及其在环境、食品和医疗领域的应用。本综述强调了3D打印生物反应器的优点，包括改善传质、优化光照、提高生物量产量和增强光合作用。还讨论了3D打印在微藻生产中的当前挑战和未来方向，以便为提高微藻培养效率以扩大应用提供新的见解。
