Wu K F, Pope J H, Ellem K A
Int J Cancer. 1985 Apr 15;35(4):477-82. doi: 10.1002/ijc.2910350410.
The growth of 7/9 Burkitt's lymphoma (BL) cell lines and 5/6 human melanoma cell lines was inhibited by certain human fibroblast-like cell lines, especially human myofibroblast cell lines. In contrast to BL lines, 3/5 lymphoblastoid cell lines were less susceptible and 3/4 human leukaemic lines were resistant. The effect was time- and concentration-dependent. Co-cultivation led to inhibition of tumour-cell growth within 3 days, but after removal from the fibroblasts, washing, and resuspending in fresh medium some tumour cells recovered and growth improved. The inhibitory activity was also demonstrated with washings of fibroblast-like cell lines, and was sensitive to pronase. The biological significance of this factor remains to be defined.
某些人成纤维细胞样细胞系，尤其是人肌成纤维细胞系，可抑制7/9的伯基特淋巴瘤（BL）细胞系和5/6的人黑色素瘤细胞系的生长。与BL细胞系相比，3/5的淋巴母细胞样细胞系较不敏感，3/4的人白血病细胞系具有抗性。这种作用具有时间和浓度依赖性。共培养在3天内导致肿瘤细胞生长受到抑制，但从成纤维细胞中移出、洗涤并重新悬浮于新鲜培养基后，一些肿瘤细胞恢复生长且生长情况改善。成纤维细胞样细胞系的洗涤液也显示出抑制活性，且对链霉蛋白酶敏感。该因子的生物学意义尚待确定。
