研究免疫衰老中性别差异的研究者指南。
A researcher's guide to studying sex differences in immune aging.
作者信息
Baker Clayton, Kim Minhoo, Benayoun Bérénice A
机构信息
Leonard Davis School of Gerontology, University of Southern California (USC), Los Angeles, CA 90089, USA; Molecular and Computational Biology Department, USC Dornsife College of Letters, Arts, and Sciences, Los Angeles, CA 90089, USA.
Leonard Davis School of Gerontology, University of Southern California (USC), Los Angeles, CA 90089, USA.
出版信息
Trends Mol Med. 2025 Jan 29. doi: 10.1016/j.molmed.2025.01.005.
Sex differences in immune system aging significantly impact disease susceptibility and vaccine responses among older adults, but with notable disparities between men and women. This area has gained importance because vaccines can exhibit differential efficacy by sex in aging populations, underscoring the need for sex-specific strategies. As the global population ages, understanding these sex-based immune differences is crucial for developing targeted interventions for age-related diseases. Addressing these disparities requires robust preclinical models that mimic human immune aging to uncover mechanisms and inform personalized approaches. In this review we assess the translational potential of preclinical mouse models in studying sex differences in immune aging, and emphasize the urgency of sex-specific interventions to improve health outcomes in older adults.
免疫系统衰老中的性别差异显著影响老年人的疾病易感性和疫苗反应，但男性和女性之间存在明显差异。这一领域变得越发重要，因为疫苗在老年人群体中可能会表现出性别差异的疗效，凸显了针对性别制定策略的必要性。随着全球人口老龄化，了解这些基于性别的免疫差异对于开发针对与年龄相关疾病的靶向干预措施至关重要。解决这些差异需要强大的临床前模型来模拟人类免疫衰老，以揭示机制并为个性化方法提供依据。在本综述中，我们评估了临床前小鼠模型在研究免疫衰老性别差异方面的转化潜力，并强调了针对性别进行干预以改善老年人健康结果的紧迫性。
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