Ahmadzadeh Amir Mahmoud, Pourbagher-Shahri Ali Mohammad, Forouzanfar Fatemeh
Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Inflammopharmacology. 2025 Feb;33(2):729-757. doi: 10.1007/s10787-024-01606-9. Epub 2025 Jan 30.
Stroke is a serious life-threatening medical condition. Understanding the underlying molecular mechanisms of this condition is crucial to identifying novel therapeutic targets that can improve patient outcomes. Autophagy is an essential mechanism for the destruction of damaged intracellular components that maintains homeostasis in physiological or pathological conditions. This process is involved in the pathophysiology of stroke. Phytochemicals are bioactive naturally occurring compounds present in plants. This paper reviews the neuroprotective roles of phytochemicals in ischemic stroke through autophagy modulation. It summarizes the interactions of various phytochemicals with key molecular targets of the autophagy pathway in ischemic stroke, including PI3K/Akt/mTOR, Beclin-1, and AMPK. Due to the ability of various phytochemicals to alter autophagic flux, they may provide promising opportunities in the development of new treatments and the improvement of stroke management.
中风是一种严重威胁生命的医学病症。了解这种病症的潜在分子机制对于确定能够改善患者预后的新治疗靶点至关重要。自噬是一种破坏受损细胞内成分的重要机制，在生理或病理条件下维持体内平衡。这个过程参与了中风的病理生理学。植物化学物质是植物中存在的具有生物活性的天然化合物。本文综述了植物化学物质通过自噬调节在缺血性中风中的神经保护作用。它总结了各种植物化学物质与缺血性中风中自噬途径关键分子靶点（包括PI3K/Akt/mTOR、Beclin-1和AMPK）之间的相互作用。由于各种植物化学物质具有改变自噬通量的能力，它们可能为开发新的治疗方法和改善中风治疗提供有前景的机会。
