Piekarski J D, Schlumberger M, Leclere J, Couanet D, Masselot J, Parmentier C
Int J Radiat Oncol Biol Phys. 1985 May;11(5):1023-7. doi: 10.1016/0360-3016(85)90126-9.
Forty thoracic CT scans have been performed on 27 patients with micronodular lung metastases of differentiated thyroid carcinoma. Lung nodules were visualized in 14 out of 19 patients (78%) with functioning lung metastases, although their chest X rays were normal. However, only a small number of peripheral micronodules can be visualized by CT scan since the central micronodules remain undistinguishable from adjacent vessel structures. A close relationship has been found between the number of micronodules and the thyroglobulin (Tg) serum level. In patients previously treated by 131I for proven lung metastases and who had no uptake for several years, but in whom Tg remained detectable in the serum, CT scans have shown micronodules in 7 of the 13 patients with normal chest X rays. The present data suggest that these nodules are mainly a result of fibrosis. CT scanning appears to be an important complementary tool with regard to 131I whole body scintigraphies in the radiologic diagnosis of lung nodules and in the assessment of radioiodine therapy.
对27例分化型甲状腺癌肺微小结节转移患者进行了40次胸部CT扫描。19例有功能性肺转移的患者中，14例（78%）的肺结节在胸部X线片正常的情况下通过CT得以显示。然而，由于中央微小结节与相邻血管结构难以区分，CT扫描只能显示少数外周微小结节。已发现微小结节数量与血清甲状腺球蛋白（Tg）水平之间存在密切关系。在先前接受过131I治疗、经证实有肺转移且数年无摄取但血清中Tg仍可检测到的患者中，13例胸部X线片正常的患者中有7例CT扫描显示有微小结节。目前的数据表明，这些结节主要是纤维化的结果。在肺结节的放射学诊断以及放射性碘治疗评估方面，CT扫描似乎是131I全身闪烁显像的重要辅助工具。
