Jung Jaegyun, Lee Sangyeon, Lee Jeong Ho, Lee Doheon
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
BJPsych Open. 2025 Jan 31;11(1):e27. doi: 10.1192/bjo.2024.845.
Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression.
To assess the associations between physical activity and self-harm behaviour and determine the recommended level of physical activity across the genotypes.
We developed the bidirectional analytical model to investigate the genotype-specific effectiveness on UK Biobank. After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations between physical activity and the risk of self-harm behaviour.
A total of 28 923 subjects with depression phenotypes were included in the study. In retrospective cohort analysis, the moderate and highly active groups were at lower risk of self-harm behaviour. In the followed prospective cohort analysis, light-intensity physical activity was associated with a lower risk of hospitalisations due to self-harm behaviour in one genetic cluster (adjusted hazard ratio, 0.28 [95% CI, 0.08-0.96]), which was distinguished by three genetic variants: rs1432639, rs4543289 and rs11209948. Compliance with the guideline-level moderate-to-vigorous physical activities was not significantly related to the risk of self-harm behaviour.
A genotype-specific dose of light-intensity physical activity reduces the risk of self-harm by around a fourth in depressive patients.
体育活动被广泛用于非药物干预以减轻抑郁症状。然而，几乎没有证据支持其在降低抑郁症患者自伤风险方面的基因型特异性有效性。
评估体育活动与自伤行为之间的关联，并确定不同基因型的推荐体育活动水平。
我们开发了双向分析模型来研究英国生物银行中基因型特异性的有效性。在使用层次聚类对抑郁症表型队列进行基因分层后，建立多变量逻辑回归模型和Cox比例风险模型来研究体育活动与自伤行为风险之间的关联。
共有28923名患有抑郁症表型的受试者纳入研究。在回顾性队列分析中，中度和高度活跃组的自伤行为风险较低。在随后的前瞻性队列分析中，轻度体育活动与一个基因簇中因自伤行为导致的住院风险较低相关（调整后的风险比，0.28 [95% CI，0.08 - 0.96]），该基因簇由三个基因变体区分：rs1432639、rs4543289和rs11209948。遵循指南水平的中度至剧烈体育活动与自伤行为风险无显著相关性。
特定基因型剂量的轻度体育活动可将抑郁症患者的自伤风险降低约四分之一。
