Shankar Hari, De Auley, Florentin Anat
The Kuvin Center for the Study of Infectious and Tropical Diseases, & Department of Microbiology and Molecular Genetics, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Indian Council of Medical Research, New Delhi, India.
IJID Reg. 2024 Sep 24;13:100463. doi: 10.1016/j.ijregi.2024.100463. eCollection 2024 Dec.
Malaria and hypertension are seemingly unrelated communicable and non-communicable diseases, both highly pervasive in the global south. There is a debate about the potential connection between these two disorders beyond any obvious factors. The emerging evidence suggests an emerging genetic selection pressure for hypertension in malaria-endemic regions. Furthermore, the impact of the liver hormone hepcidin, which has been overlooked, is significant in the development of hypertension due to malaria. Malaria exposure leads to changes in iron metabolism through the regulation of hepcidin, resulting in iron deficiency and, consequently, the development of hypertension.
疟疾和高血压看似是不相关的传染病和非传染病，在全球南方地区都极为普遍。关于这两种疾病之间除了任何明显因素之外的潜在联系存在争议。新出现的证据表明，在疟疾流行地区，高血压正面临新出现的基因选择压力。此外，一直被忽视的肝脏激素铁调素，在疟疾导致的高血压发展过程中具有重要影响。接触疟疾会通过调节铁调素导致铁代谢发生变化，从而造成缺铁，进而引发高血压。
