≤10处转移灶的结直肠癌患者接受单次亚消融放疗联合全身治疗的可行性和安全性：一项多中心试点研究（NCT05375708）
Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708).
作者信息
Zwart K, Braat M N G J A, van der Baan F H, May A M, Roodhart J M L, Al-Toma D, Otten J M M B, Los M, Oostergo T, Fijneman R J A, van Dodewaard-de Jong J M, Punt C J A, Meijer G, Lagendijk J J W, Koopman M, Intven M, Bol G M
机构信息
Department of Medical Oncology, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
出版信息
Clin Transl Radiat Oncol. 2024 Oct 6;49:100874. doi: 10.1016/j.ctro.2024.100874. eCollection 2024 Nov.
Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.
在一项单臂、开放标签、多中心的试点研究（天狼星研究）中，对≤10个不可切除转移灶的结直肠癌患者，除了给予标准的全身治疗外，还接受了单次分割亚消融放疗，以评估其可行性和安全性。结果表明，放疗联合全身治疗在该人群中是可行且安全的。
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