Goldstein Daniel A, Saltz Leonard B, Pond Gregory R, Tannock Ian F
Medical Oncology, Rabin Medical Center Davidoff Cancer Center, Petah Tikva, Central, Israel.
Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
BMJ Oncol. 2024 Jan 30;3(1):e000287. doi: 10.1136/bmjonc-2023-000287. eCollection 2024.
In the field of general medicine, class effects, or therapeutic interchangeability, have been declared for several families of drugs including statins, calcium channel blockers and ACE inhibitors. The existence of such class effects enables healthcare payers to negotiate for substantially lower drug prices, thereby reducing financial toxicity, both at an individual and societal levels. Until now, the existence of class effects in oncology has been considered rare. Here, we review evidence from clinical trials that supports the existence of class effects for several types of anticancer drugs. These class effects in oncology should be exploited to reduce healthcare costs.
在普通医学领域，已宣布包括他汀类药物、钙通道阻滞剂和血管紧张素转换酶抑制剂在内的几个药物家族存在类效应或治疗可互换性。此类类效应的存在使医疗保健支付方能够就大幅降低药品价格进行谈判，从而在个人和社会层面降低经济毒性。到目前为止，肿瘤学中类效应的存在一直被认为很罕见。在此，我们回顾了来自临床试验的证据，这些证据支持几种抗癌药物存在类效应。肿瘤学中的这些类效应应被用于降低医疗保健成本。
