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人类免疫缺陷病毒/获得性免疫综合征(HIV/AIDS)感染者中的妊娠相关系统性红斑狼疮

Pregnancy-associated systemic lupus erythematosus in people living with HIV/AIDS.

作者信息

Mendiratta Vibhu, Yadav Anukriti

机构信息

Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.

出版信息

Indian J Sex Transm Dis AIDS. 2024 Jul-Dec;45(2):121-125. doi: 10.4103/ijstd.ijstd_100_23. Epub 2024 Oct 18.

DOI:10.4103/ijstd.ijstd_100_23
PMID:39886240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11776914/
Abstract

Pregnancy with systemic lupus erythematosus (SLE) requires special attention in view of the enhanced risks to the fetus and the aggravation of SLE during pregnancy. Human immunodeficiency virus infection can further complicate the course of pregnancy as well as the outcome. We present a case of a 28-year-old primigravida who was diagnosed case of people living with HIV/AIDS and presented with SLE at 34 weeks of gestation. Subsequent evaluation of the patient revealed latent tuberculosis also. Cutaneous lesions responded well to oral corticosteroids, however, the outcome of pregnancy was hydrops fetalis. This report highlights the complex interplay of multiple comorbidities and their adverse impact on pregnancy outcome.

摘要

鉴于系统性红斑狼疮(SLE)患者怀孕时胎儿面临的风险增加以及孕期SLE病情加重,此类妊娠需要特别关注。人类免疫缺陷病毒感染会使妊娠过程及结局进一步复杂化。我们报告一例28岁初产妇,她被诊断为感染人类免疫缺陷病毒/获得性免疫综合征,在妊娠34周时出现SLE。对该患者的后续评估还发现了潜伏性结核。皮肤病变对口服皮质类固醇反应良好,但妊娠结局为胎儿水肿。本报告强调了多种合并症之间复杂的相互作用及其对妊娠结局的不利影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/79899c850a6b/IJSTD-45-121-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/4c183086a0ac/IJSTD-45-121-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/dc87dd7cd03c/IJSTD-45-121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/bfaafd1b3fbc/IJSTD-45-121-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/1cb271088b4e/IJSTD-45-121-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/79899c850a6b/IJSTD-45-121-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/4c183086a0ac/IJSTD-45-121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/d4250838142f/IJSTD-45-121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/a8eeb2efa19c/IJSTD-45-121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/dc87dd7cd03c/IJSTD-45-121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/bfaafd1b3fbc/IJSTD-45-121-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/1cb271088b4e/IJSTD-45-121-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea95/11776914/79899c850a6b/IJSTD-45-121-g007.jpg

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本文引用的文献

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Tuberculosis Among Patients With Systemic Lupus Erythematosus in Indonesia: A Cohort Study.印度尼西亚系统性红斑狼疮患者中的结核病:一项队列研究
Open Forum Infect Dis. 2022 Apr 12;9(7):ofac201. doi: 10.1093/ofid/ofac201. eCollection 2022 Jul.
2
Systemic Lupus Erythematosus Management in Pregnancy.妊娠期系统性红斑狼疮的管理
Int J Womens Health. 2022 Feb 15;14:199-211. doi: 10.2147/IJWH.S282604. eCollection 2022.
3
Systemic lupus erythematosus in HIV: An insight into clinical implications and management.HIV感染中的系统性红斑狼疮:对临床意义及管理的见解
Indian J Sex Transm Dis AIDS. 2019 Jan-Jun;40(1):64-66. doi: 10.4103/ijstd.IJSTD_26_18.
4
Systemic Lupus Erythematosus and Pregnancy: A Brief Review.系统性红斑狼疮与妊娠:简要综述
J Obstet Gynaecol India. 2019 Apr;69(2):104-109. doi: 10.1007/s13224-019-01212-8. Epub 2019 Mar 12.
5
Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients.系统性红斑狼疮患者队列中的人类免疫缺陷病毒。
Adv Rheumatol. 2018 Jul 11;58(1):12. doi: 10.1186/s42358-018-0003-2.
6
The interplay between tuberculosis and systemic lupus erythematosus.结核分枝杆菌感染与系统性红斑狼疮的相互作用。
Curr Opin Rheumatol. 2018 Jul;30(4):395-402. doi: 10.1097/BOR.0000000000000493.
7
Understanding and Managing Pregnancy in Patients with Lupus.狼疮患者妊娠的理解与管理
Autoimmune Dis. 2015;2015:943490. doi: 10.1155/2015/943490. Epub 2015 Jul 12.