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卡波西肉瘤免疫重建炎症综合征：如今一个被遗忘的实体。

Kaposi's sarcoma immune reconstitution inflammatory syndrome: A forgotten entity nowadays.

作者信息

Cristina Fernández Romero, Lorena Vila Cobreros, Tamara Fenollosa Sanz, Juan Flores Cid, Marta Valero Núñez, Carlos Puglia Santos Víctor, Andrea Galeano Paniagua Laura, Rafael Carmena Ramón, Esther Quecedo Estébanez

机构信息

Department of Dermatology, Arnau de Vilanova Hospital, Valencia, Spain.

Department of Oncology, Arnau de Vilanova Hospital, Valencia, Spain.

出版信息

Indian J Sex Transm Dis AIDS. 2024 Jul-Dec;45(2):151-154. doi: 10.4103/ijstd.ijstd_57_24. Epub 2024 Dec 13.

DOI:10.4103/ijstd.ijstd_57_24
PMID:39886246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11776904/
Abstract

The appearance of antiviral therapy has led to a change in the prognosis and clinical manifestations of patients with human immunodeficiency virus infections and Kaposi's sarcoma. However, there are still countries in which access is inadequate and the disease progresses toward disseminated forms with an unfavorable outcome. We present two patients who presented with skin lesions that progressed for a month, compatible with disseminated Kaposi's sarcoma in the context of HIV. One month after starting treatment, they were admitted for multi-organ failure associated with an Immune reconstitution inflammatory syndrome and eventually died.

摘要

抗病毒治疗的出现改变了人类免疫缺陷病毒感染和卡波西肉瘤患者的预后及临床表现。然而，仍有一些国家存在治疗可及性不足的情况，疾病会进展为播散型，预后不佳。我们报告了两名患者，他们出现皮肤病变达一个月，符合人类免疫缺陷病毒背景下的播散型卡波西肉瘤。开始治疗一个月后，他们因与免疫重建炎症综合征相关的多器官衰竭入院，最终死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/2ca5e096281c/IJSTD-45-151-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/98708e430a77/IJSTD-45-151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/17f641127417/IJSTD-45-151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/43e23dd82be6/IJSTD-45-151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/b1e6f6148d67/IJSTD-45-151-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/fac2d8c73cdb/IJSTD-45-151-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/2ca5e096281c/IJSTD-45-151-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/98708e430a77/IJSTD-45-151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/17f641127417/IJSTD-45-151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/43e23dd82be6/IJSTD-45-151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/b1e6f6148d67/IJSTD-45-151-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/fac2d8c73cdb/IJSTD-45-151-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b009/11776904/2ca5e096281c/IJSTD-45-151-g006.jpg

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本文引用的文献

1
Immune Reconstitution Inflammatory Syndrome Associated Kaposi Sarcoma.免疫重建炎症综合征相关的卡波西肉瘤
Cancers (Basel). 2022 Feb 16;14(4):986. doi: 10.3390/cancers14040986.
2
Experience with Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome in a Large Urban HIV Clinic in the United States: Case Series and Literature Review.美国一家大型城市艾滋病诊所的卡波西肉瘤疱疹病毒炎性细胞因子综合征经验：病例系列与文献综述
Open Forum Infect Dis. 2017 Sep 13;4(4):ofx196. doi: 10.1093/ofid/ofx196. eCollection 2017 Fall.
3
Clinical characteristics, predictors of immune reconstitution inflammatory syndrome and long-term prognosis in patients with Kaposi sarcoma.
卡波西肉瘤患者的临床特征、免疫重建炎症综合征的预测因素及长期预后
AIDS Res Ther. 2017 May 30;14(1):30. doi: 10.1186/s12981-017-0156-9.
4
Clinical Features and Outcomes of Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-associated Inflammation: Prospective Characterization of KSHV Inflammatory Cytokine Syndrome (KICS).有症状的卡波西肉瘤疱疹病毒（KSHV）相关炎症患者的临床特征和结局：KSHV炎性细胞因子综合征（KICS）的前瞻性特征分析
Clin Infect Dis. 2016 Mar 15;62(6):730-738. doi: 10.1093/cid/civ996. Epub 2015 Dec 12.
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Steroids are a risk factor for Kaposi's sarcoma-immune reconstitution inflammatory syndrome and mortality in HIV infection.类固醇是卡波西肉瘤免疫重建炎症综合征的一个危险因素，也是HIV感染患者死亡的危险因素。
AIDS. 2016 Mar 27;30(6):909-14. doi: 10.1097/QAD.0000000000000993.
6
Risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs. deferred ART during an opportunistic infection.机会性感染时早期与延迟 ART 随机研究中免疫重建炎症综合征的风险因素分析。
PLoS One. 2010 Jul 1;5(7):e11416. doi: 10.1371/journal.pone.0011416.