2023年11月至2024年6月香港儿童流感疫苗对流感相关住院治疗的有效性
Influenza vaccine effectiveness against influenza-associated hospitalizations in children, Hong Kong, November 2023 to June 2024.
作者信息
Lee So-Lun, Kwan Mike Y W, Murphy Caitriona, Chan Eunice L Y, Wong Joshua S C, Sullivan Sheena G, Peiris Malik, Cowling Benjamin J
机构信息
Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region.
出版信息
Vaccine X. 2024 Oct 6;20:100570. doi: 10.1016/j.jvacx.2024.100570. eCollection 2024 Oct.
We conducted a test negative study from November 2023 to June 2024, enrolling 4,367 children hospitalized with acute respiratory illness in Hong Kong. Among the children who tested negative for influenza virus and SARS-CoV-2, 56.8 % had received influenza vaccination. Between November 2023 and March 2024, influenza A(H3N2) predominated and the VE against influenza A(H3N2) was estimated as 55 % (95 % CI: 29.6 %, 71.8 %). VE point estimates were higher for younger children than older children. In February to June 2024 influenza A(H1N1) predominated and VE against influenza A(H1N1) was 54 % (95 % CI: 33 %, 69 %) during this period. Influenza B/Victoria circulated at low intensity throughout the 2023/24 season and VE against influenza B was 66 % (95 % CI: 42 %, 80 %). Since its introduction in 2018/19 the school-based influenza vaccination program has substantially increased vaccine uptake in children in Hong Kong and prevented influenza-associated hospitalizations.
我们在2023年11月至2024年6月期间开展了一项检测阴性研究，纳入了4367名在香港因急性呼吸道疾病住院的儿童。在流感病毒和SARS-CoV-2检测呈阴性的儿童中，56.8%接种过流感疫苗。在2023年11月至2024年3月期间，甲型流感（H3N2）占主导，针对甲型流感（H3N2）的疫苗效力估计为55%（95%置信区间：29.6%，71.8%）。年幼儿童的疫苗效力点估计值高于年长儿童。在2024年2月至6月期间，甲型流感（H1N1）占主导，在此期间针对甲型流感（H1N1）的疫苗效力为54%（95%置信区间：33%，69%）。乙型流感/维多利亚系在整个2023/24季节以低强度传播，针对乙型流感的疫苗效力为66%（95%置信区间：42%，80%）。自2018/19学年引入以来，香港的学校流感疫苗接种计划大幅提高了儿童的疫苗接种率，并预防了与流感相关的住院病例。
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