美国国家健康与营养检查调查中氧化平衡评分与青光眼之间的关联。
Association between oxidative balance score and glaucoma in the National Health and Nutrition Examination Survey.
作者信息
Huang Jun, Zhang Yulan, Wu Chao, Wu Yifan, Wang Feiran, Ning Yunxuan, Shi Lu
机构信息
Department of Ophthalmology, The Second Affiliated Hospital, Nanchang University, Nanchang, China.
出版信息
Front Nutr. 2025 Jan 15;12:1528114. doi: 10.3389/fnut.2025.1528114. eCollection 2025.
OBJECTIVE
To investigate the association between Oxidative Balance Score (OBS) and glaucoma risk.
METHODS
Using data from the National Health and Nutrition Examination Survey (2005-2008), we analyzed 2,615 participants aged ≥40 years. OBS was calculated from 15 antioxidant and 5 pro-oxidant components, including dietary nutrients and lifestyle factors. Glaucoma was identified through self-reported diagnosis and retinal imaging. Survey-weighted logistic regression and restricted cubic splines (RCS) were used to assess associations.
RESULTS
Higher OBS was associated with lower glaucoma risk (adjusted OR = 0.97, 95% CI: 0.94-1.00). Participants in the highest OBS quartile showed 51% lower odds of glaucoma compared to the lowest quartile (adjusted OR = 0.49, 95% CI: 0.27-0.90). The protective effect was more pronounced among middle-aged adults (40-60 years; OR = 0.90, 95% CI: 0.86-0.95) and males (OR = 0.93, 95% CI: 0.90-0.97).
CONCLUSION
Higher OBS were associated with lower glaucoma prevalence, particularly among middle-aged adults and males, suggesting potential benefits of maintaining oxidative balance in glaucoma prevention.
目的
研究氧化平衡评分（OBS）与青光眼风险之间的关联。
方法
利用美国国家健康与营养检查调查（2005 - 2008年）的数据，我们分析了2615名年龄≥40岁的参与者。OBS由15种抗氧化成分和5种促氧化成分计算得出，包括膳食营养素和生活方式因素。青光眼通过自我报告诊断和视网膜成像来确定。采用调查加权逻辑回归和限制性立方样条（RCS）来评估关联。
结果
较高的OBS与较低的青光眼风险相关（调整后的比值比[OR]=0.97，95%置信区间[CI]：0.94 - 1.00）。与最低四分位数相比，OBS最高四分位数的参与者患青光眼的几率低51%（调整后的OR = 0.49，95% CI：0.27 - 0.90）。这种保护作用在中年成年人（40 - 60岁；OR = 0.90，95% CI：0.86 - 0.95）和男性（OR = 0.93，95% CI：0.90 - 0.97）中更为明显。
结论
较高的OBS与较低的青光眼患病率相关，尤其是在中年成年人和男性中，这表明在青光眼预防中维持氧化平衡可能具有潜在益处。
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