Chen Zhihong, Jiang Shitao, Liu Yaoge, Zhang Ting, Zheng Han, Mao Yunhan, Zhang Lei, Xu Yiyao, Lu Xin
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Chronobiol Int. 2025 Feb;42(2):185-197. doi: 10.1080/07420528.2025.2456560. Epub 2025 Jan 31.
Research linking circadian dysregulation to cancer development has received increasing attention recently. However, a comprehensive understanding of research hotspots and trends in this area remains limited. International studies on the circadian rhythms in cancer were retrieved and downloaded from the Web of Science database. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and HistCite. Three thousand three hundred and eighteen English articles from 2004 to 2024 were screened and evaluated. The increase in publications and citations reflected the rapid expansion of the field. Scholars and institutions in the United States have relatively high academic productivity and impact. Chronobiology International is the most popular journal. Key clustering analysis identified six themes: biochemistry and molecular biology, physiology and immunomodulation, night shift work and health effects, physiological and mental health, tumor therapy research, and oxidative stress and cancer-related mechanisms. Keyword burst analysis identified the regulation of circadian rhythms on cells and tumor microenvironment as the research frontiers. The role of circadian rhythms in tumor immunotherapy was a current research hotspot identified by reference co-citation clustering analysis. This study reveals the current status of research on the circadian rhythms in cancer and predicts future trends. These findings provide new ideas for developing novel cancer prevention and treatment strategies.
将昼夜节律失调与癌症发展联系起来的研究近来受到了越来越多的关注。然而，对该领域研究热点和趋势的全面理解仍然有限。从科学网数据库中检索并下载了关于癌症昼夜节律的国际研究。使用VOSviewer、CiteSpace和HistCite进行文献计量分析和可视化。筛选并评估了2004年至2024年的3318篇英文文章。出版物数量和引用次数的增加反映了该领域的迅速扩展。美国的学者和机构具有较高的学术生产力和影响力。《国际时间生物学》是最受欢迎的期刊。关键聚类分析确定了六个主题：生物化学与分子生物学、生理学与免疫调节、夜班工作与健康影响、生理与心理健康、肿瘤治疗研究以及氧化应激与癌症相关机制。关键词突现分析确定了昼夜节律对细胞和肿瘤微环境的调节为研究前沿。昼夜节律在肿瘤免疫治疗中的作用是通过参考文献共被引聚类分析确定的当前研究热点。本研究揭示了癌症昼夜节律的研究现状并预测了未来趋势。这些发现为制定新的癌症预防和治疗策略提供了新思路。
