Yin Yu, Yang Tiezheng, Tian Ziyue, Shi Chong, Yan Chengqiu, Li Hui, Du Yu, Li Guofeng
The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, PR China.
Hainan Provincial People's Hospital, Haikou 570100, PR China.
J Med Microbiol. 2025 Jan;74(1). doi: 10.1099/jmm.0.001966.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that presents significant challenges in terms of treatment owing to a pronounced likelihood of recurrence and an elevated risk of cancer development, thereby imposing substantial risks on affected individuals. The gut microbiota of Firmicutes and Bacteroidetes (F/B) can affect diseases associated with IBD, which is also a risk factor for breast cancer. This review discusses the hazards associated with UC, highlights the existing disparities in UC-associated gut microbiome research, explores the concept of the F/B ratio and scrutinizes its correlation with UC. Moreover, the differences in the F/B ratios between healthy individuals and those with UC were thoroughly examined. These findings suggest that an elevated F/B ratio may promote the occurrence and progression of UC. Consequently, the F/B ratio may play a significant role in UC by influencing gut microbiota composition and inflammatory responses, suggesting that future research should focus on this ratio as a potential biomarker for disease progression and therapeutic targets in managing UC.
溃疡性结肠炎（UC）是一种慢性炎症性肠病（IBD），由于复发可能性高和癌症发生风险增加，在治疗方面面临重大挑战，从而给受影响个体带来巨大风险。厚壁菌门和拟杆菌门（F/B）的肠道微生物群可影响与IBD相关的疾病，这也是乳腺癌的一个风险因素。本综述讨论了与UC相关的危害，强调了UC相关肠道微生物组研究中存在的差异，探讨了F/B比率的概念，并审视了其与UC的相关性。此外，还对健康个体与UC患者之间的F/B比率差异进行了全面研究。这些发现表明，F/B比率升高可能促进UC的发生和发展。因此，F/B比率可能通过影响肠道微生物群组成和炎症反应在UC中发挥重要作用，这表明未来的研究应将该比率作为疾病进展的潜在生物标志物以及管理UC的治疗靶点。
