Aliakbarlu Javad, Manafi Leila, Mortazavi Negar, Lin Lin, Kaboudari Ata
Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Health Products Safety Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Crit Rev Food Sci Nutr. 2025 Jan 31:1-15. doi: 10.1080/10408398.2025.2458742.
Food-borne pathogenic bacteria cause infection and death in humans, and impose great economic losses in the food industry worldwide annually. Therefore, researchers have turned to the use of different types of antimicrobials to control pathogenic bacteria in foods. Due to the side effects of synthetic antimicrobials, much attention has recently been paid to natural ones. Endolysins, enzymes coded by bacteriophages, and their derivatives have been known as natural and safe antimicrobials which may be used to eliminate or reduce pathogenic bacteria in foods and their processing environments. Endolysins are remarkably stable under different conditions, and therefore they may have broader use in the food industry. In addition to describing the structure and production of endolysins, this review provides almost comprehensive information on using endolysins as antimicrobials against food-borne pathogens and in food models, and against their biofilms. According to the results of published studies, endolysins can be considered as a very suitable alternative to synthetic antimicrobials. The use of endolysins to control food-borne pathogens and increase food safety assurance level have been emphasized due to the rapid and specific action of the endolysins, their good stability, and lack of resistance development to endolysins in bacteria.
食源性病原体可导致人类感染和死亡，并每年在全球食品工业中造成巨大经济损失。因此，研究人员已转向使用不同类型的抗菌剂来控制食品中的病原菌。由于合成抗菌剂的副作用，近年来天然抗菌剂备受关注。内溶素是由噬菌体编码的酶，及其衍生物已被认为是天然且安全的抗菌剂，可用于消除或减少食品及其加工环境中的病原菌。内溶素在不同条件下具有显著的稳定性，因此它们在食品工业中可能有更广泛的用途。除了描述内溶素的结构和生产外，本综述还提供了几乎全面的信息，包括使用内溶素作为针对食源性病原体、在食品模型中以及针对其生物膜的抗菌剂。根据已发表研究的结果，内溶素可被视为合成抗菌剂的非常合适的替代品。由于内溶素的快速和特异性作用、良好的稳定性以及细菌对内溶素不会产生抗性，因此强调了使用内溶素来控制食源性病原体并提高食品安全保障水平。
