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Evaluation of Small Airways Dysfunction With Dupilumab Using Airway Oscillometry in Uncontrolled Severe Asthma.

作者信息

Stewart Kirsten E, Kuo Chris RuiWen, Chan Rory, Lipworth Brian J

机构信息

Scottish Centre for Respiratory Research, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK.

出版信息

Clin Exp Allergy. 2025 Mar;55(3):264-266. doi: 10.1111/cea.70002. Epub 2025 Jan 30.

DOI:10.1111/cea.70002
PMID:39887823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11908834/
Abstract
摘要

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本文引用的文献

1
Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor.严重哮喘中Muc5AC增加和纤毛细胞减少通过抑制IL-4Rα受体得到部分恢复。
Am J Respir Crit Care Med. 2024 Dec 15;210(12):1409-1420. doi: 10.1164/rccm.202307-1266OC.
2
Identifying poorer asthma control using oscillometry ratios.使用振荡法比率识别哮喘控制较差的情况。
J Allergy Clin Immunol Pract. 2024 Feb;12(2):506-508.e1. doi: 10.1016/j.jaip.2023.10.048. Epub 2023 Nov 3.
3
Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-Controlled Trial.度普利尤单抗对中重度哮喘患者黏液阻塞和通气缺陷的影响:一项随机、双盲、安慰剂对照试验。
Am J Respir Crit Care Med. 2023 Nov 1;208(9):995-997. doi: 10.1164/rccm.202306-1102LE.
4
Real-life effects of dupilumab on airway oscillometry in severe uncontrolled asthma.度普利尤单抗对重度未控制哮喘患者气道振荡法测定的实际影响。
Ann Allergy Asthma Immunol. 2023 Nov;131(5):664-666. doi: 10.1016/j.anai.2023.07.021. Epub 2023 Jul 28.
5
Repeatability of impulse oscillometry in patients with severe asthma.重度哮喘患者脉冲振荡法的可重复性
Eur Respir J. 2021 Dec 31;59(1). doi: 10.1183/13993003.01679-2021. Print 2022 Jan.
6
IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways.白细胞介素 13(IL-13)和白细胞介素 4(IL-4)而非白细胞介素 5(IL-5)和白细胞介素 17A(IL-17A)可诱导离体人小气道产生高反应性。
J Allergy Clin Immunol. 2020 Mar;145(3):808-817.e2. doi: 10.1016/j.jaci.2019.10.037. Epub 2019 Dec 2.
7
Is small airways dysfunction related to asthma control and type 2 inflammation?小气道功能障碍与哮喘控制及2型炎症有关吗?
Ann Allergy Asthma Immunol. 2018 Nov;121(5):631-632. doi: 10.1016/j.anai.2018.08.009. Epub 2018 Aug 19.
8
Small airway dysfunction is associated with poorer asthma control.小气道功能障碍与哮喘控制不佳相关。
Eur Respir J. 2014 Nov;44(5):1353-5. doi: 10.1183/09031936.00082314. Epub 2014 Jul 17.
9
The forced oscillation technique in clinical practice: methodology, recommendations and future developments.临床实践中的强迫振荡技术:方法、建议及未来发展
Eur Respir J. 2003 Dec;22(6):1026-41. doi: 10.1183/09031936.03.00089403.