白细胞介素-23/白细胞介素-17轴的基因变异及其与牙周病的关联：一项系统评价

Genetic Variants of the IL-23/IL-17 Axis and Its Association With Periodontal Disease: A Systematic Review.

作者信息

Rodríguez-Montaño Ruth, Alarcón-Sánchez Mario Alberto, Lomelí-Martínez Sarah Monserrat, Martínez-Bugarin Cristina Hermila, Heboyan Artak

机构信息

Department of Health and Illness as an Individual and Collective Process, University Center of Tlajomulco, University of Guadalajara (CUTLAJO-UdeG), Tlajomulco de Zuñiga, Mexico.

Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico.

出版信息

Immun Inflamm Dis. 2025 Feb;13(2):e70147. doi: 10.1002/iid3.70147.

DOI:10.1002/iid3.70147

PMID:39887950

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11783687/

Abstract

BACKGROUND

The objective of this systematic review was to identify genetic variants of the IL-23, IL-17, IL-23R and IL-17R genes and isoforms and its possible association with increased development of periodontitis and peri-implantitis.

METHODS

A systematic review was prepared according to the guidelines, registered in the OSF database with the registration number: 10.17605/OSF. IO/X95ZC. The electronic search was performed in four databases: PubMed, Scopus, Web of Science, and Google Scholar from 1984 until March 15th, 2024. The JBI Critical Appraisal Checklist for Case-Control Studies was used to assess the quality of included studies.

RESULTS

Eighteen papers with a case-control design were those that ultimately met the eligibility criteria. A total of 3904 individuals (2315 with periodontitis and 90 with peri-implantitis), and 1589 healthy subjects) were studied. The age range of the study population was 14-70 years, with a mean age ± (SD) of 40.43 ± 6.33 years. A total of 28 genetic variants corresponding to the IL-17A (rs 2275913, rs 3819024, rs 10484879) IL-17F (rs 763780), IL-17R (rs 879576) and IL-23R (rs 11209026) genes were analyzed in this study. Six (33.3%) studies found an association between the IL-17A 197 G/A (rs 2275913) genetic variant and peri-implantitis and periodontitis. One study (5.5%) found an association between the IL-17A rs10484879 variant and peri-implantitis and periodontitis.

CONCLUSION

Six polymorphisms were evaluated, highlighting rs 2275913 of the cytokine IL-17A in patients with periodontitis or peri-implantitis. Only 50% of studies found an association despite having a small sample. This suggests that other factors such as the degree of disease, systemic diseases and ethnic groups studied may play a role.

摘要

背景

本系统评价的目的是确定白细胞介素-23（IL-23）、白细胞介素-17（IL-17）、白细胞介素-23受体（IL-23R）和白细胞介素-17受体（IL-17R）基因及亚型的遗传变异，及其与牙周炎和种植体周围炎发病增加之间的可能关联。

方法

根据指南进行系统评价，并在开放科学框架（OSF）数据库中注册，注册号为：10.17605/OSF.IO/X95ZC。从1984年至2024年3月15日，在四个数据库中进行电子检索：PubMed、Scopus、科学网和谷歌学术。采用JBI病例对照研究关键评价清单评估纳入研究的质量。

结果

最终有18篇病例对照设计的论文符合纳入标准。共研究了3904名个体（2315名牙周炎患者和90名种植体周围炎患者）以及1589名健康受试者。研究人群的年龄范围为14至70岁，平均年龄±（标准差）为40.43±6.33岁。本研究分析了与IL-17A（rs 2275913、rs 3819024、rs 10484879）、IL-17F（rs 763780）、IL-17R（rs 879576）和IL-23R（rs 11209026）基因对应的28个遗传变异。六项（33.3%）研究发现IL-17A 197G/A（rs 2275913）遗传变异与种植体周围炎和牙周炎之间存在关联。一项研究（5.5%）发现IL-17A rs10484879变异与种植体周围炎和牙周炎之间存在关联。