Mansour Reda M, Abdel Mageed Sherif S, Abulsoud Ahmed I, Sayed Ghadir A, Lutfy Radwa H, Awad Farah A, Sadek Mohamed M, Shaker Abanoub A S, Mohammed Osama A, Abdel-Reheim Mustafa Ahmed, Elimam Hanan, Doghish Ahmed S
Zoology and Entomology Department, Faculty of Science, Helwan University, Helwan, 11795, Egypt.
Biology Department, School of Biotechnology, Badr University in Cairo, Badr City, 11829, Cairo, Egypt.
Funct Integr Genomics. 2025 Jan 31;25(1):30. doi: 10.1007/s10142-025-01544-x.
Non-alcoholic fatty liver disease (NAFLD) is a disease with various levels varying from fatty liver steatosis to acute steatosis which is non-alcoholic steatohepatitis (NASH), which can develop into hepatic failure, as well as in some conditions it can develop into hepatocellular carcinoma (HCC). In the NAFLD and NASH context, aberrant microRNA (miRNA) expression has a thorough contribution to the incidence and development of these liver disorders by influencing key biological actions, involving lipid metabolism, inflammation, and fibrosis. Dysregulated miRNAs can disrupt the balance between lipid accumulation and clearance, exacerbate inflammatory responses, and promote fibrogenesis, thus advancing the severeness of the disorder from simple steatosis to more complex NASH. In the current review, the latest development concerned with the activity of complex regulatory networks of miRNA in the incidence as well as the evolution of NAFLD is to be discussed, also conferring about the miRNAs' role in the onset, pathogenesis as well as diagnosis of NAFLD and NASH discussing miRNAs' role as diagnostic biomarkers and their therapeutic effects on NAFLD/NASH.
非酒精性脂肪性肝病（NAFLD）是一种具有不同程度的疾病，从脂肪肝脂肪变性到非酒精性脂肪性肝炎（NASH）这种急性脂肪变性，后者可发展为肝衰竭，在某些情况下还可发展为肝细胞癌（HCC）。在NAFLD和NASH背景下，异常的微小RNA（miRNA）表达通过影响关键生物学行为，包括脂质代谢、炎症和纤维化，对这些肝脏疾病的发生和发展有全面的影响。失调的miRNA会破坏脂质积累与清除之间的平衡，加剧炎症反应，并促进纤维化，从而使疾病的严重程度从单纯脂肪变性发展到更复杂的NASH。在本综述中，将讨论与miRNA复杂调控网络在NAFLD发生及发展过程中的活性相关的最新进展，还将探讨miRNA在NAFLD和NASH的发病、发病机制及诊断中的作用，讨论miRNA作为诊断生物标志物的作用及其对NAFLD/NASH的治疗效果。
