Bai Lina, Yang Xuying, Miao Huali, Shi Hong, Zhang Hong, Fu Xiaoxia, Li Wanling
Department of Rheumatology and Immunology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China.
Infection Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China.
West J Nurs Res. 2025 Mar;47(3):149-158. doi: 10.1177/01939459251314967. Epub 2025 Jan 31.
Systemic lupus erythematosus (SLE) is characterized by a range of symptoms that often cluster together, impacting the quality of life (QoL) of affected individuals.
To delineate the composition of symptom clusters in patients with SLE and analyze their correlation with QoL, thus providing a basis for symptom management.
Using convenience sampling, 201 patients were recruited. Data were collected using a general information questionnaire, SLE Symptom Checklist and Lupus Quality of Life scale. Symptom clusters were identified using exploratory factor analysis, and their correlations with QoL were analyzed using Spearman correlation analysis.
The most common symptom among patients was fatigue (64.7%). Five symptom clusters were identified: fatigue-related symptoms, weight gain-related symptoms, itch-pain-related symptoms, skin change symptoms, and body image symptoms. Fatigue-related, weight gain-related, and body image symptom clusters showed significant negative correlations with overall QoL scores and scores in various dimensions ( < .05). The itch-pain symptom cluster was negatively correlated with the total score of QoL and several dimensions such as pain status, burden status, mental health status, physical health status, and fatigue status ( < .05). The skin change symptom cluster was negatively correlated with the total score of QoL and several dimensions, such as mental health, physical health, and fatigue status ( < .05).
Patients with SLE exhibit significant symptom clusters correlating with overall QoL. Such data highlight the need for nurses to evaluate symptom clusters and intervene in related factors, enhancing QoL.
系统性红斑狼疮（SLE）的特征是一系列症状常常聚集出现，影响患者的生活质量（QoL）。
明确SLE患者症状群的构成，并分析其与生活质量的相关性，从而为症状管理提供依据。
采用便利抽样法，招募了201例患者。使用一般信息问卷、SLE症状清单和狼疮生活质量量表收集数据。采用探索性因子分析确定症状群，并使用Spearman相关分析分析其与生活质量的相关性。
患者中最常见的症状是疲劳（64.7%）。确定了五个症状群：疲劳相关症状、体重增加相关症状、瘙痒-疼痛相关症状、皮肤改变症状和身体形象症状。疲劳相关、体重增加相关和身体形象症状群与总体生活质量得分及各维度得分呈显著负相关（<0.05）。瘙痒-疼痛症状群与生活质量总分以及疼痛状况、负担状况、心理健康状况、身体健康状况和疲劳状况等几个维度呈负相关（<0.05）。皮肤改变症状群与生活质量总分以及心理健康、身体健康和疲劳状况等几个维度呈负相关（<0.05）。
SLE患者存在与总体生活质量相关的显著症状群。这些数据凸显了护士评估症状群并干预相关因素以提高生活质量的必要性。
