扫频源可见光光学相干断层扫描术

Swept-source visible-light optical coherence tomography.

作者信息

Fan Weijia, Kuranov Roman, Miller David A, Zhang Tingwei, Yeo Wei-Hong, Atkinson Raymond, Zhang Pengpeng, Sun Cheng, Zhang Hao F

出版信息

Opt Lett. 2025 Feb 1;50(3):928-931. doi: 10.1364/OL.544499.

DOI:10.1364/OL.544499

PMID:39888790

Abstract

We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). We used a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG) to convert a commercial near-infrared swept-source (NIR-SS) laser into a visible-light SS laser. To enhance SHG efficiency, we amplified the NIR-SS output with booster optical amplifiers (BOAs) and generated up to 580 µW of power. The SS-vis-OCT achieved a maximum axial resolution of 7.3 µm and an imaging depth of 5 mm in air, corresponding to 5.4 µm and 3.7 mm in tissue (n = 1.35). Compared with spectral-domain vis-OCT, SS-vis-OCT provides a 2.2-fold increased imaging depth and a 2.8-fold improved roll-off. Additionally, we validated SS-vis-OCT performance using a 3D-printed pyramid phantom, with its feature measurements cross-validated by scanning electron microscopy (SEM).

摘要

我们展示了扫频源可见光光学相干断层扫描（SS-vis-OCT）的可行性。我们使用扇形输出周期性极化铌酸锂（PPLN）晶体进行二次谐波产生（SHG），将商用近红外扫频源（NIR-SS）激光器转换为可见光SS激光器。为提高SHG效率，我们用光增强放大器（BOA）放大NIR-SS输出，产生了高达580 µW的功率。SS-vis-OCT在空气中实现了7.3 µm的最大轴向分辨率和5 mm的成像深度，在组织中分别对应5.4 µm和3.7 mm（n = 1.35）。与谱域vis-OCT相比，SS-vis-OCT的成像深度增加了2.2倍，滚降改善了2.8倍。此外，我们使用3D打印金字塔模型验证了SS-vis-OCT的性能，其特征测量通过扫描电子显微镜（SEM）进行交叉验证。