Yip Raymond K H, Hawkins Edwin D, Bowden Rory, Rogers Kelly L
Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia; Colonial Foundation Diagnostics Centre, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia; Colonial Foundation Diagnostics Centre, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Semin Cell Dev Biol. 2025 Mar;167:10-21. doi: 10.1016/j.semcdb.2025.01.001. Epub 2025 Jan 30.
The tissue microenvironment refers to a localised tissue area where a complex combination of cells, structural components, and signalling molecules work together to support specific biological activities. A prime example is the bone marrow microenvironment, particularly the hematopoietic stem cell (HSC) niche, which is of immense interest due to its critical role in supporting lifelong blood cell production and the growth of malignant cells. In this review, we summarise the current understanding of HSC niche biology, highlighting insights gained from advanced imaging and genomic techniques. We also discuss the potential of emerging technologies such as spatial multi-omics to unravel bone marrow architecture in unprecedented detail.
组织微环境是指局部组织区域，其中细胞、结构成分和信号分子的复杂组合共同作用以支持特定的生物学活动。一个典型的例子是骨髓微环境，特别是造血干细胞（HSC）龛，由于其在支持终身血细胞生成和恶性细胞生长方面的关键作用而备受关注。在本综述中，我们总结了目前对HSC龛生物学的理解，突出了从先进成像和基因组技术中获得的见解。我们还讨论了空间多组学等新兴技术以前所未有的细节揭示骨髓结构的潜力。
