• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

强力霉素硬化疗法作为头颈部巨大囊状水瘤的主要治疗方法:一项病例报告研究

Doxycycline sclerotherapy as a primary treatment of head and neck giant cystic hygroma: A case report study.

作者信息

Al-Saadie Waddah

机构信息

Otolaryngology Department, Damascus Hospital, Damascus, Syria.

出版信息

Int J Surg Case Rep. 2025 Feb;127:110945. doi: 10.1016/j.ijscr.2025.110945. Epub 2025 Jan 25.

DOI:10.1016/j.ijscr.2025.110945
PMID:39889658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11834124/
Abstract

INTRODUCTION

Cystic hygroma is a benign lymphatic malformation, developing around 6th gestational week. The big challenge is in the way they are managed due to their extension within the vital elements. Treatment options include watchful waiting, surgery, sclerotherapy and combination between them in some cases.

CASE PRESENTATION

We present a rare case of giant cystic hygroma of a 11-month-old male was referred to the Department of Otolaryngology for an asymptomatic, aesthetically unappealing swelling in the neck since 9 months. A well-defined large cystic mass measures about (4 × 7 × 9 cm) was seen in the CT scan, originating at the left lateral neck. It extends from the left submandibular space inferiorly posterior to the sternocleidomastoid muscle, and retrosternally to the aortic arch level. From the Posterior aspect, the mass reaches the prevertebral space. No lymph adenopathy was noted. No bony erosions. Findings are suggestive of Cystic Higroma (CH).The primary treatment was sclerotherapy using doxycycline for one time. The procedure was performed at an operating theatre under general anesthesia because injection of the sclerosant factor is painful. The child was monitored for 3 months after the procedure (with an interval of one month between each observation). There was a noticeable improvement after 4 weeks and the complete resolution of the cystic hygroma was observed 12 weeks after the initial procedure. During the monitoring period of 6 months, the lesion did not show any recurrence.

CLINICAL DISCUSSION

In this case of giant Cystic Higroma (CH) significantly decreased after using of Doxycycline sclerotherapy for one time only without the need to repeat the procedure more than once. So clinicians should be aware of this good treatment of (CH) because it offers minimal patient trauma and excellent outcomes.

CONCLUSION

Through the good results we have reached from this case, we encourage its application extensively in the future to more cases due to their safety and quick results.

摘要

引言

囊状水瘤是一种良性淋巴管畸形,在妊娠第6周左右形成。由于其在重要结构内的延伸,对其治疗是一项巨大挑战。治疗选择包括密切观察、手术、硬化治疗,在某些情况下还包括它们之间的联合应用。

病例报告

我们报告一例罕见的11个月大男性巨大囊状水瘤病例,自9个月大起因颈部无症状但外观不佳的肿胀被转诊至耳鼻喉科。CT扫描显示一个边界清晰的大囊性肿块,大小约为(4×7×9厘米),起源于左侧颈部。它从左下颌下间隙向下延伸至胸锁乳突肌后方,胸骨后至主动脉弓水平。从后面看,肿块延伸至椎前间隙。未发现淋巴结肿大。无骨质侵蚀。检查结果提示为囊状水瘤(CH)。主要治疗方法是使用强力霉素进行一次硬化治疗。该操作在全身麻醉下于手术室进行,因为注射硬化剂会引起疼痛。术后对患儿进行了3个月的监测(每次观察间隔1个月)。4周后有明显改善,初次治疗12周后观察到囊状水瘤完全消退。在6个月的监测期内,病变未显示任何复发迹象。

临床讨论

在该例巨大囊状水瘤(CH)病例中,仅使用一次强力霉素硬化治疗后明显缩小,无需重复该操作。因此,临床医生应了解这种对(CH)的良好治疗方法,因为它对患者的创伤最小且效果极佳。

结论

通过该病例取得的良好结果,我们鼓励未来因其安全性和快速疗效而在更多病例中广泛应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/c8cc6316ed79/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/9beaa792ce3d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/7ead53f62e50/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/062fdce5b3d4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/390e5986b0ef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/28b95877c9ff/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/11a90da8a58e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/c8cc6316ed79/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/9beaa792ce3d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/7ead53f62e50/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/062fdce5b3d4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/390e5986b0ef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/28b95877c9ff/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/11a90da8a58e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4157/11834124/c8cc6316ed79/gr7.jpg

相似文献

1
Doxycycline sclerotherapy as a primary treatment of head and neck giant cystic hygroma: A case report study.强力霉素硬化疗法作为头颈部巨大囊状水瘤的主要治疗方法:一项病例报告研究
Int J Surg Case Rep. 2025 Feb;127:110945. doi: 10.1016/j.ijscr.2025.110945. Epub 2025 Jan 25.
2
Case report: - A case report on adult-onset cystic hygroma and literature review.病例报告:- 一例成人期囊状水瘤病例报告及文献综述。
Int J Surg Case Rep. 2024 Dec;125:110595. doi: 10.1016/j.ijscr.2024.110595. Epub 2024 Nov 12.
3
[Cystic hygroma : report of 25 cases].[囊状水瘤:25例报告]
Tunis Med. 2012 Jan;90(1):19-24.
4
OK-432 Sclerotherapy of Giant Cervicomediastinal Cystic Hygroma.OK-432 硬化疗法治疗巨大颈纵隔囊性淋巴管瘤。
J Craniofac Surg. 2022;33(8):e810-e812. doi: 10.1097/SCS.0000000000008692. Epub 2022 Sep 6.
5
Efficacy of doxycycline and sodium tetradecyl sulfate sclerotherapy in pediatric head and neck lymphatic malformations.强力霉素和十四烷基硫酸钠硬化疗法治疗小儿头颈部淋巴管畸形的疗效
Int J Pediatr Otorhinolaryngol. 2015 Jun;79(6):883-887. doi: 10.1016/j.ijporl.2015.03.024. Epub 2015 Apr 6.
6
[Airway obstruction due to cystic hygroma in a newborn].[新生儿囊状水瘤导致气道阻塞]
Bol Med Hosp Infant Mex. 2014 Jul-Aug;71(4):233-237. doi: 10.1016/j.bmhimx.2014.07.001. Epub 2015 May 19.
7
Doxycycline sclerotherapy in children with head and neck lymphatic malformations.多西环素硬化疗法治疗儿童头颈部淋巴管畸形
J Pediatr Surg. 2015 Dec;50(12):2143-6. doi: 10.1016/j.jpedsurg.2015.08.051. Epub 2015 Sep 4.
8
Role of Bleomycin Sclerotherapy as a Non-surgical Method for the Treatment of Cystic Hygroma of Head and Neck Region-an Institutional Study.博来霉素硬化疗法作为头颈部囊性水瘤非手术治疗方法的作用——一项机构研究
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):2553-2559. doi: 10.1007/s12070-020-02273-2. Epub 2020 Nov 16.
9
Adult-onset giant cervical cystic hygroma with pressure manifestations on aerodigestive tract, managed surgically: reporting of a rare case.成人期巨大颈部囊状水瘤伴气道消化道受压表现,手术治疗:1例罕见病例报告
Ann R Coll Surg Engl. 2019 Mar;101(3):e84-e87. doi: 10.1308/rcsann.2018.0214. Epub 2019 Jan 3.
10
The Curious Case of Fibrofatty Conversion of Cystic Hygroma Treated with Bleomycin Sclerotherapy.用博来霉素硬化疗法治疗囊状水瘤纤维脂肪转化的奇闻病例。
J Cutan Aesthet Surg. 2020 Jul-Sep;13(3):229-232. doi: 10.4103/JCAS.JCAS_152_19.

本文引用的文献

1
The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines.SCARE 2023 指南:更新共识外科病例报告(SCARE)指南。
Int J Surg. 2023 May 1;109(5):1136-1140. doi: 10.1097/JS9.0000000000000373.
2
Efficacy and Clinical Outcomes of Bleomycin in the Treatment of Lymphangiomas: A Multicenter Experience.博来霉素治疗淋巴管瘤的疗效和临床结局:多中心经验。
Dermatol Surg. 2021 Jul 1;47(7):948-952. doi: 10.1097/DSS.0000000000002976.
3
Is multiple session of intralesional bleomycin mandatory for complete resolution of macrocystic lymphatic malformation?
对于大囊型淋巴管畸形的完全消退,多次瘤内注射博来霉素是必需的吗?
Indian J Plast Surg. 2018 Jan-Apr;51(1):60-65. doi: 10.4103/ijps.IJPS_154_17.
4
Surgical management of adult-onset cystic hygroma in the axilla.成人腋窝淋巴管瘤的外科治疗
Int J Surg Case Rep. 2015;7C:29-31. doi: 10.1016/j.ijscr.2014.11.017. Epub 2014 Nov 11.
5
OK432 versus doxycycline for treatment of macrocystic lymphatic malformations.溶链菌制剂OK432与强力霉素治疗大囊型淋巴管畸形的比较
Ann Otol Rhinol Laryngol. 2014 Feb;123(2):81-8. doi: 10.1177/0003489414523561.
6
Percutaneous sclerotherapy of cystic lesions.囊性病变的经皮硬化治疗
Semin Intervent Radiol. 2012 Dec;29(4):295-300. doi: 10.1055/s-0032-1330063.
7
The ex utero intrapartum treatment (EXIT) procedure: application of a new therapeutic paradigm.产时宫外治疗(EXIT)手术:一种新治疗模式的应用
J Paediatr Child Health. 2013 Sep;49(9):E420-7. doi: 10.1111/jpc.12223. Epub 2013 May 13.
8
Doxycycline sclerotherapy in children with lymphatic malformations: outcomes, complications and clinical efficacy.多西环素硬化治疗儿童淋巴管畸形:疗效、并发症及临床疗效。
Pediatr Radiol. 2012 Sep;42(9):1080-8. doi: 10.1007/s00247-012-2406-2. Epub 2012 May 31.
9
Treatment guidelines of lymphatic malformations of the head and neck.头颈部淋巴管畸形治疗指南。
Oral Oncol. 2011 Dec;47(12):1105-9. doi: 10.1016/j.oraloncology.2011.08.001. Epub 2011 Sep 8.
10
Cystic hygroma: an overview.囊状水瘤:概述
J Cutan Aesthet Surg. 2010 Sep;3(3):139-44. doi: 10.4103/0974-2077.74488.