Qin Bowen, Li Zhe, Xia Guozhi, Wang Xu, Bai Ruhai
National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Key laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China; Department of Digital Oral Implantology and Prothodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
J Affect Disord. 2025 Apr 15;375:380-389. doi: 10.1016/j.jad.2025.01.122. Epub 2025 Jan 30.
Limited studies have investigated the association between depressive symptoms and napping habits. In this study, nationally representative data from the China Health and Retirement Longitudinal Study (CHARLS) were employed to conduct cross-sectional and longitudinal analyses to investigate their associations among Chinese middle-aged and older adults.
The study included 12,208 participants from the 2015 CHARLS. Depressive symptoms were measured using the Depression Scale. Napping duration was categorized into four groups: no napping (0 min), short (<30 min), moderate (30-89 min), and prolonged (≥90 min). Logistic regression analysis was used to assess bidirectional relationships, and dose-response patterns were analyzed via restricted cubic splines (RCS).
A total of 2487 participants (32.0 %) developed new-onset depressive symptoms, and moderate napping group exhibited the lowest incidence rate. Statistical analysis revealed that moderate napping was a protective factor for the depressive symptoms (OR, 95 % CI, 0.689, 0.567-0.843). A total of 1742 participants (42.3 %) newly experienced poor napping, and the incidence of poor napping gradually rose by the increase of the CES-D-10 score quartiles. Moreover, depressive symptoms were also found to be a risk factor for poor napping (OR, 95 % CI, 1.149, 1.004-1.314). The RCS model revealed that there was an approximately U-shaped association between nap duration and depressive symptoms, and there was a negative linear association between CES-D-10 scores and nap duration.
The observational design limits ruling out unobserved confounding factors.
There was a significant bidirectional relationship and a dose-response association between napping and depressive symptoms in middle-aged and older adults.
仅有有限的研究调查了抑郁症状与午睡习惯之间的关联。在本研究中,采用了来自中国健康与养老追踪调查(CHARLS)具有全国代表性的数据进行横断面和纵向分析,以研究中国中老年人群中二者的关联。
该研究纳入了2015年CHARLS的12208名参与者。使用抑郁量表测量抑郁症状。午睡时长分为四组:无午睡(0分钟)、短午睡(<30分钟)、中等午睡(30 - 89分钟)和长午睡(≥90分钟)。采用逻辑回归分析评估双向关系,并通过受限立方样条(RCS)分析剂量反应模式。
共有2487名参与者(32.0%)出现新发抑郁症状,中等午睡组的发病率最低。统计分析显示,中等午睡是抑郁症状的保护因素(比值比,95%置信区间,0.689,0.567 - 0.843)。共有1742名参与者(42.3%)新出现午睡质量差的情况,且随着CES - D - 10评分四分位数的增加,午睡质量差的发生率逐渐上升。此外,抑郁症状也是午睡质量差的危险因素(比值比,95%置信区间,1.149,1.004 - 1.314)。RCS模型显示,午睡时长与抑郁症状之间存在近似U型关联,且CES - D - 10评分与午睡时长之间存在负线性关联。
观察性设计限制了对未观察到的混杂因素的排除。
中老年人群的午睡与抑郁症状之间存在显著的双向关系和剂量反应关联。