Langer T P
J Comp Neurol. 1985 May 1;235(1):38-47. doi: 10.1002/cne.902350104.
We have shown that the monkey flocculus is not connected with any of the major, well-demarcated cerebellar nuclei. There is, however, a broadly distributed interstitial population of neurons in the white matter ventral to the cerebellar nuclei and extending into the peduncle of the flocculus; this population, previously undescribed in the monkey, has reciprocal connections with the flocculus (Langer et al., '85a,b). Several lines of evidence indicate that this collection of neurons, called the basal interstitial nucleus of the cerebellum (BIN/Cb), can justifiably be considered a nucleus. (1) Injection of horseradish peroxidase (HRP) into the flocculus always labels a group of neurons that lie immediately ventral to the well-demarcated cerebellar nuclei and extend posteromedially into the lateral margin of the nodulus and rostrolaterally around the caudal surface of the y-group, infiltrating the peduncle of the flocculus. (2) In Nissl-stained material there is a readily seen collection of neurons that are clearly distinct from the overlying cerebellar nuclei, with precisely the same distribution. These neurons have a characteristic morphology: they are intermediate-sized, chromatophilic, multipolar, and fusiform, and have rapidly tapering proximal dendrites. The cell nucleus is generally placed eccentrically in the cell body, against the plasma membrane or in one pole of the cell. The Nissl substance is usually finely granular in the center of the cell body and forms dense clumps adjacent to the cell membrane. (3) Anterograde label from injections of HRP or tritiated amino acids into the flocculus extends over the same group of neurons. In one brain with an HRP injection involving a part of the BIN/Cb there was a patchy, clustered distribution of labeled Purkinje cells extending throughout the flocculus and into the adjacent lateral parts of the simple lobule. The clusters were confined to the medial half of many of the floccular folia.
我们已经表明，猕猴的绒球与任何主要的、界限分明的小脑核均无连接。然而，在小脑核腹侧的白质中存在着广泛分布的神经元间质群体，并延伸至绒球脚；这一群体在猕猴中此前未被描述过，它与绒球有相互连接（兰格等人，1985a，b）。几条证据表明，这一神经元集合，即小脑基底间质核（BIN/Cb），有理由被视为一个核。（1）将辣根过氧化物酶（HRP）注入绒球，总是会标记出一组神经元，这些神经元位于界限分明的小脑核正腹侧，并向后内侧延伸至小结的外侧边缘，围绕y组尾侧表面向 rostrolaterally 延伸，渗透到绒球脚。（2）在尼氏染色材料中，可以很容易地看到一组明显不同于上方小脑核的神经元集合，其分布完全相同。这些神经元具有特征性形态：它们中等大小、嗜色、多极且呈梭形，近端树突迅速变细。细胞核通常偏心地位于细胞体内，靠在质膜上或位于细胞的一极。尼氏体物质在细胞体中心通常呈细颗粒状，并在细胞膜附近形成密集的团块。（3）将HRP或氚标记氨基酸注入绒球后的顺行标记延伸至同一组神经元。在一个因HRP注射涉及部分BIN/Cb的大脑中，有标记的浦肯野细胞呈斑片状、聚集分布，贯穿整个绒球并延伸至简单小叶的相邻外侧部分。这些簇局限于许多绒球小叶的内侧半部分。
