Wade M H, Plotnick H
J Am Acad Dermatol. 1985 Mar;12(3):515-21. doi: 10.1016/s0190-9622(85)70072-2.
We present the identification and characterization of two patients with xeroderma pigmentosum (XP) and squamous cell carcinoma of the tongue. Dermal fibroblasts from two black siblings with XP were shown to be hypersensitive to ultraviolet (UV) light measured by colony-forming ability. UV-induced unscheduled deoxyribonucleic acid synthesis was reduced significantly when compared with normal levels for both strains. The strains were assigned to complementation group C on the basis of cell fusion studies. Patients with XP have a marked increase over normal persons for developing skin cancer, presumably because of their extreme sensitivity to UV light. Our results may have applicability in explaining the in vivo development of epidermoid carcinoma in the partially shielded tongue of some XP patients.
我们报告了两例患有着色性干皮病（XP）和舌鳞状细胞癌患者的鉴定与特征。通过集落形成能力测定，来自两名患有XP的黑人同胞的皮肤成纤维细胞对紫外线（UV）敏感。与两种菌株的正常水平相比，紫外线诱导的非预定脱氧核糖核酸合成显著降低。基于细胞融合研究，这些菌株被归为互补组C。XP患者患皮肤癌的几率比正常人显著增加，可能是因为他们对紫外线极度敏感。我们的结果可能有助于解释一些XP患者部分受保护的舌部表皮样癌的体内发展情况。
