细胞RNA作为一种抗病毒的线粒体抗病毒信号蛋白（MAVS）信号小体支架。
Cellular RNA acts as an antiviral MAVS signalosome scaffold.
作者信息
Liu Yang, Cao Xuetao
机构信息
Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Trends Immunol. 2025 Feb;46(2):97-99. doi: 10.1016/j.it.2025.01.003. Epub 2025 Jan 30.
The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing antiviral signaling and interferon expression to inhibit viral infection.
衔接蛋白线粒体抗病毒信号蛋白（MAVS）介导的先天性免疫反应对于宿主抵御RNA病毒至关重要。戈哈尔及其同事报告称，细胞信使核糖核酸（mRNA）通过直接结合MAVS并调节其相互作用分子来组装并激活MAVS信号小体，从而增强抗病毒信号传导和干扰素表达以抑制病毒感染。
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